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The G protein-coupled receptors (GPCRs), known to be one of the largest superfamilies in the human genome, underpin a multitude of physiological processes and represent a significant target for bioactive and drug discovery programs. In G Protein-Coupled Receptors in Drug Discove…
GTPase protocols: the Ras superfamily
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Type: Book
Edward J. Manser and Thomas Leung have collected the key techniques currently in use to probe the function of these ubiquitous proteins both in vitro and in vivo. Presented in a format that ensures ready reproducibility by accomplished experimentalists who have refined the vario…
Small GTPase binding proteins (GTPases) are an ancient group of proteins that play key roles in almost every aspect of cell biology, from cell proliferation to nuclear transport. In GTPase Protocols: The Ras Superfamily, Edward J. Manser and Thomas Leung have collected the key t…
P2Y receptors are G protein-coupled receptors activated by extracellular nucleotides. Although eleven receptors have been proposed to be P2Y receptors, only five (P2Y\sb1,\ P2Y\sb2,\ P2Y\sb4,\ P2Y\sb6, and P2Y₁₁) have been shown to be functional mammalian P2Y receptors. This dis…
G Proteins: Techniques of Analysis covers essential methods - with a commitment to those techniques of proven and current utility. G Proteins: Techniques of Analysis includes expression and functions analysis of G proteins; evaluation of covalent modifications and other regulato…