1. Introduction. 1.1. Discovery of AID. 1.2. Current model of AID function. 1.3. Open questions. 1.4. A unifying model for AID function. 1.5. Acknowledgements. 1.6. References -- 2. Switch regions, chromatin accessibility and AID targeting. 2.1. Introduction. 2.2. Transcriptiona…
This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch re…
Anticarbohydrate Antibodies
by Kosma, Paul, Kosma, Paul, Müller-Loennies, Sven, Mèuller-Loennies, Sven
Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached cl…
Anticarbohydrate Antibodies -- from molecular basis to clinical application compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relev…
Over the last decade, major advances in our understanding of the immune system and its mechanisms have led to promising new treatment strategies. In Adoptive Immunotherapy: Methods and Protocols, leading experts describe in detail their optimal techniques for producing and chara…
Antibodies are an indispensable tool in the study of biology and medicine. Making and Using Antibodies: A Practical Handbook presents techniques in a single, comprehensive source for the production and use of antibodies. It enables researchers to immediately access lab-tested, p…