The work described herein has explored solid-phase transduction of nucleic acid hybridization on platforms composed of paper substrates, and also glass surfaces within glass/polydimethylsiloxane microfluidic channels. Single-stranded probe oligonucleotides were conjugated to qua…
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The information age is upon us. We generate, process, store, display and transmit information in ever-increasing amounts. Sensing and measuring is one aspect of information generation that has become an increasingly important activity in the modern time. Sensors can be categoriz…
The objective of this dissertation is to develop a mesoscopic multiscale particle based computational method, extend its applicability to state-of-the-art problems and simulate microfluidic processes at mesoscale, An in-house comprehensive computational package based on dissipat…
Genetic analysis is not widely used for disease diagnostics as it is costly and very labour/infrastructure intensive. We believe that by employing both microelectronic and microfabrication technologies, we are able to integrate multiple functionalities into a single, manufactura…
Dielectrophoresis, a nonlinear electrokinetic transport mechanism, becomes popular in many engineering and biomedical applications for manipulation, characterization and actuation of biomaterials, particles and biological cells. However, the underlying fundamental mechanism of d…
This experimental study investigates the feasibility of using a lens-less charge-coupled device (CCD) for the detection of organic and inorganic fluorophores. The study further investigates the feasibility of this device as a detection sensor in a hand-held Point-of-Care (POC) m…
Existing microfluidic devices transport fluids by a variety of physical means. Among them, pump-based and capillary-based fluid delivery systems are commonly adapted to move fluids. The pump-based systems intrinsically require sub systems consisting of mechanical and/or electric…
In this thesis work, designs were developed and implemented for separating plasma from a droplet of whole blood in an active and passive Lab-on-Chip (LOC) device. Nine filters were tested and compared to establish a process of elimination based on the filtration properties and p…
For the past decade, new research fields utilizing microfluidics have been formed. General micro-integration methods were proposed, and the supporting fundamental technologies were widely developed. These methodologies have made various applications in the fields of analytical a…
For the past decade, new research fields utilizing microfluidics have been formed. General micro-integration methods were proposed, and the supporting fundamental technologies were widely developed. These methodologies have made various applications in the fields of analytical a…