"This book describes the status of clinical trials related to siRNA-based cancer therapy, as well as the remaining issues that need to be overcome to establish a successful therapy. It, then introduces various promising design strategies of delivery vehicles for stable and targe…
This detailed book provides a comprehensive state-of-the-art presentation of all aspects of miRNA target identification, from the prediction of miRNA binding sites on their target molecules to their experimental validation and downstream functional analysis. It also explores met…
The rapid pace of microRNA (miRNA) research continues to drive the advances of techniques for miRNA expression profiling, and innovative technologies that are more sensitive, specific, quantitative, and that are compatible with a wide range of biospecimens have been developed du…
The rapid pace of microRNA (miRNA) research continues to drive the advances of techniques for miRNA expression profiling, and innovative technologies that are more sensitive, specific, quantitative, and that are compatible with a wide range of biospecimens have been developed du…
This second edition presents an up-to-date overview of the current state-of-the-art protocols and aims to put the miRNomics into a broader perspective. Chapters detail methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to thei…
Understanding the relationships between DNA sequence and organismal phenotypes has been a central goal across a wide variety of biological subdisciplines throughout the history of genetics research. Studies of the developmental genetic mechanisms underlying phenotypes aim to inc…
Insufficient maternal folate during pregnancy increases the risk of the baby being small for gestational age (SGA). Studies in teenagers, a population vulnerable to folate deficiency and SGA birth, have shown that low maternal folate status is associated with impaired placental …
There has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases. This book reviews the emerging role of microRNAs in cerebral ischemia, providing comprehensive details of the links between this small RNA molecule and is…
There has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases. This book reviews the emerging role of microRNAs in cerebral ischemia, providing comprehensive details of the links between this small RNA molecule and is…
There has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases. This book reviews the emerging role of microRNAs in cerebral ischemia, providing comprehensive details of the links between this small RNA molecule and is…
MicroRNAs play an important role in biological regulation. Recently miR-34a has been reported to regulate tumour cell cycle progression and apoptosis. However, the functional role of miR-34a in smooth muscle cell (SMC) differentiation from stem cells is yet unclear. Main objecti…
