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Provides diverse, novel, and useful descriptions of miRNAs in several species, including plants, worms, flies, fish, chicks, mice, and humans. These include some useful adaptations and applications that could be relevant to the wider research community who are already familiar w…
It is now known that microRNA (miRNA), once thought to be junk, can suppress the expression of other genes and may be involved in numerous cellular processes, including cell proliferation, apoptosis, cell differentiation, and development. In MicroRNA Protocols, expert miRNA rese…
This book summarizes the latest findings on the functions of microRNAs in the regulation of plant development and responses to the surrounding environment. MicroRNAs are an important class of molecules that can be found in diverse groups of organisms, including plants and animal…
Over the past 30 years, mammalian cell culture has enabled the production of recombinant protein therapeutics for treatment of a broad range of debilitating or life-threatening diseases. Continual improvements in cell and process engineering have facilitated the attainment of on…
Consolidation of nascent memory into long lasting forms involves synaptic plasticity. Even in the relatively simple brain of Drosophila , memory evolves in neural location and temporal stability. While distinct biochemical mechanisms likely act on the neural pathways that acquir…
microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation miRNAs are single-stranded RNAs of ∼22 nucleotides, which repress protein expression at a post-transcriptional level. Mechanistically, base pairing of the miRNA 'seed' re…
Previous studies in our group revealed the existence of truncated forms of T cell receptor β (TCRβ) mRNA in mesenchymal cells. The expression of truncated TCRβ mRNA was not restricted to mesenchyme. Indeed, such transcripts were found also in the thymus. The present study was ai…