The design of new, improved NO-donor drugs is an important pharmacological objective due to the biological importance of nitric oxide. N-Hydroxyguanidines represent a useful class of NO donors where the mechanism of action is based on the biosynthetic pathway for NO. Thirty new …
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Plasma membrane calcium/calmodulin-dependent calcium ATPases (PMCAs) are high affinity calcium pumps regulating many calcium-dependent processes and advances in its characterisation have discovered that it may play a novel role in signal transduction pathways. It was the aim of …
Introduction: Nitric oxide (NO) is an integral molecule implicated in the control of vascular function. It has been suggested that vascular dysfunction may lead to the development of acute mountain sickness (AMS), high-altitude cerebral oedema (HACE) and high-altitude pulmonary …
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric o…
"This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complex…
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric o…
Cardiovascular disease (CVD) is the world-leading cause of mortality. The pathophysiological process underlying CVD is atherosclerosis, often preceded by dysfunction of the endothelium, the inner layer of the artery wall. The endothelium is sensitive to hemodynamic stimuli, incl…
Since the discovery of cytoglobin (Cygb) a decade ago, growing amounts of data have been gathered to characterise Cygb biochemistry, functioning and implication in human pathologies. Its molecular roles remain under investigation, but nitric oxide dioxygenase and lipid peroxidas…
In this study we show firstly the differences in physiologic response and tissue outcome on two distinct ischemic models, comparing hemodynamic, inflammatory, and histological parameters. The open window chamber model was utilized in Golden Syrian hamsters and tourniquet or comp…
Tetrahydrobiopterin (BH4) is an essential cofactor for neuronal nitric oxide synthase (nNOS), yet the question of whether neurons that secrete nitric oxide (NO) synthesize BH4 remains unanswered. Cerebellar granule cell cultures (CGC) offer a model system of NO-producing neurons…
Throughout the twentieth century, Japanese noh drama was a major creative catalyst for American and European writers, dancers, and composers. The noh theater's stylized choreography, poetic chant, spectacular costumes and masks, and engagement with history inspired Western artis…