The US healthcare system faces numerous challenges. In this dissertation I study issues of access to care, healthcare costs, and responses to the opioid epidemic. I take an applied economic approach, using causal inference methods to examine the effects of recent policies and ch…
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In Egypt, pharmaceutical prices are set by the Ministry of Health and Population (MOHP). For decades, the ministry used a cost-plus method to set prices. This method has been criticized as being inflexible as it does not account for inflation or the currency exchange rate's fluc…
Many studies have focused on the negative impact of globalization on the conditions of people in third world countries by highlighting labor cost-reduction mechanisms. This dissertation looks at the role of revenue-increasing market mechanisms which are aimed at increasing profi…
The challenges of achieving the new vision in pharmacy education have been cited as an important reason for advocating transformational leadership as the kind of educational leadership that is required to assist the pharmacy profession in creating a patient centered practice. Ba…
The nation's pharmacy administration has evolved significantly from the pharmacist performing only dispensing related activity in the past to present, conducting daily patient monitoring by being in the vicinity of the patient care units. With an increase in pharmacist's respons…
Modern design of controlled release delivery systems deviates from the use of standard polymeric materials available and concentrates on development of novel biopolymers. In this study, new synthetic linear and cross-linked ampholytic polyelectrolytes consisting of tertiary amin…
Although the use of vaccines is a major strategy in the control of poultry diseases, not all vaccines are very effective, and this is true particularly in the case of the existing Salmonella vaccines. In this study three new approaches to improve the delivery system and the qual…
Two types of hairless Peromyscus maniculatus mice (type-1 and type-2) were evaluated as an in vitro skin model for transdermal drug delivery studies and were compared to SKH-1 hairless mouse and human cadaver skins. The study contained the evaluation of the gender effect and the…
Composites that contain hydrophilic particles dispersed uniformly within a hydrophobic network have been investigated. Theoretical issues that governed release characteristics have been defined and validated experimentally. When the hydrophilic content is below the percolation t…
This dissertation examines the connections between global capitalism, modern medicine, and empire through a close study of Hoshi Pharmaceuticals during the interwar years. As one of the leading drug companies in East Asia at the time, Hoshi embodied Japan's imperial aspirations,…
A survey was undertaken to assess the knowledge, attitudes and practices, with respect to malaria, of 300 women from six randomly selected rural communities in Central Ethiopia from December 1991 to February 1992. Eighty-five per cent were able to recognize one or more of the co…
The objective of this study was to explore the pilosebaceous unit (PSU) route as a target for topical delivery and to determine the effect of formulation on drug delivery to PSU and other skin strata. A variety of in vitro and in vivo deposition studies as well as pharmacodynami…
The purpose of this study was to conduct a resource utilization and economic analysis on the use of carboplatin versus cisplatin over multiple cycles in lung (non-small cell = NSCLC; small cell = SCLC) and ovarian cancer. The objective was to measure and compare direct medical r…
Theory. Drug permeability is one of the most important parameters that influence oral absorption. It is currently being determined by jejunal perfusion with the Loc-I-Gut method. This method was shown to be successful in effective permeability estimation applying the well mixed …
Diltiazem, a tertiary amine, has a high systemic clearance mainly due to extensive hepatic metabolism. This suggests that processes or drugs that can modulate hepatic blood flow and enzyme activity have the potential to alter the kinetics of diltiazem. In humans diltiazem shows …
La dyskinésie induite á la L-Dopa se manifeste sous forme des mouvements anormaux et involontaires survenant suite á l'administration pulsatile et à long terme de L-Dopa chez les patients parkinsoniens. Il s'agit d'une complication fréquente, invalidante, dont le traitement médi…
A phytochemical study of Homalium zeylanicum led to the isolation of eight novel and several known compounds. Salirepin, salireposide and the three related analogs, homaloside B, C and D are being reported as occurring in a species of the Flacourtiaceae for the first time. This …