The vitamin folic acid has received considerable attention in the 1990s because of its preventative role against diseases such as neural tube defects, cardiovascular diseases, and psychiatric illness. A primary concern is the pharmaceutical quality, potency, and efficacy of comm…
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My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. …
There is a clear association between excessive exposure to estrogens and the development of cancer in several tissues including breast and endometrium. Premarin is the most widely dispensed prescription for estrogen replacement therapy in the U.S.A. in 1995. It contains 46% endo…
Crude extracts from 40 Iranian and Canadian plants were tested for their antifungal activity against several species of Aspergillus, Candida, and Cryptococcus. The extracts of Diplotaenia damavandica, Heracleum persicum, Sanguisorba minor, and Zataria multiflora exhibited the wi…
Khat (Catha edulis) is a green leafy plant that is traditionally chewed for its mainly mild stimulant effects throughout East Africa and the Arabian Peninsula since the 11th century. Khat leaves contain the active compound known as cathinone, which is structurally and chemically…
Various nasal formulations have been tested for their suitability to deliver drug through nasal cavity. This route is especially of interest where dose of drug is small and the drug may undergo an extensive first-pass metabolism and/or decomposition while passing through the gas…
The present study highlights the prospects of introducing starch acetate as an excipient for coating multi-particulate beads for controlled drug delivery. Starch acetate with high dS was synthesized from native corn starch using the aqueous paste disintegrated method followed by…
The dose dependent pharmacokinetics of 7,12-dimethylbenz(a)anthracene have been studied in male Sprague-Dawley rats following intravenous injection of 5 mg/kg - 50 mg/kg. No effects in the disposition parameters were observed as a function of dose if 5 mg/kg dose was not include…
The castrated golden Syrian hamster develops renal adenocarcinoma when subjected to estradiol or diethylstilbesterol (DES) over a nine month period. This tumor is not only estrogen-induced but also estrogen-dependent; therefore, it is considered an experimental model for estroge…
A complete characterization of the physicochemical characteristics of famotidine is lacking in the literature. Although famotidine is commercially available in tablet, powder for suspension and intravenous injection forms, no oral solution dosage form is yet available. Also, the…
Liposomes have been investigated for their potential to stabilize drugs with which they become associated. Acetylsalicylic acid, local anesthetics, and cefotaxime sodium were selected as model compounds for this evaluation. The kinetics of hydrolysis in liposomes were studied as…
Through bioactivity-directed fractionation, six cytotoxic constituents have been characterized from the bark of Plumeria rubra L. collected in Bandung, Java, Indonesia. Three iridoids, fulvoplumierin, allamcin, and allamandin, as well as 2,5-dimethoxy-p-benzoquinone, were found …
Two anhydrous water-soluble ointment bases, E-3 and E-4, were evaluated as ophthalmic vehicles. Both exhibited low irritation potential in rabbits' eyes. Base E-3 contained polyethylene glycols 200 and 400 thickened by an amine-neutralized Carbopol('R) 940 resin to form a stable…
Bioactivity-guided fractionation of a chloroform extract of the aerial parts of Baccharis articulata (Lam.) Pers. has led to the isolation of two known compounds that were significantly active against the P-388 lymphocytic leukemia cell line, namely, apigenin and methyl-3-(3,4-d…
A microencapsulation technique involving interfacial reaction of nonaqueous solutions of salts of organic bases emulsified in aqueous solutions of salts of weakly acidic macromolecules was developed at Temple University. As part of the characterization of these microparticles it…
In this dissertation, the effects of: (a) alcohol and dietary restriction of tyrosine/phenylalanine (tyr/phe) or methionine on natural killer (NK) cell activity, (b) tyr/phe deficiency on polyinosinic-polycytidylic acid (poly I:C) augmentation of NK cell reactivity, and (c) tyr/…
In phytochemical work conducted, separate collections of the leaves, twigs, and bark of Aglaia edulis were acquired from Indonesia, as part of an ongoing investigation on the discovery of new anticancer agents from plants. Two new cyclopenta[b]benzofurans, aglaroxin A 1-O-acetat…
Lung cancer is the leading cause of cancer death in the U.S. in both men and women. While 5-fluorouracil (5-FU) is an effective chemotherapeutic agent, it is not used in lung cancer because of its high toxicity and unfavorable pharmacokinetics. Nevertheless, preliminary reports …