Prostate -- Cancer

Native-born (born in the United States) and Caribbean-born African-American males bear a disproportionate burden of prostate cancer morbidity and mortality. However, few studies have examined differences between Native-born males and Caribbean-born African-American males, and th…

RRR-α-tocopheryl succinate (VES) is known to inhibit the proliferation of numerous cancer cell types. Previous studies have illustrated VES's ability to induce DNA synthesis arrest, increase activation of latent transforming growth factor-β (TGF-β), and promote apoptosis. Three …

Nucleolin, an abundant cellular protein, has been recognized as a therapeutic target in gene therapy treatments for cancer. Structural studies to facilitate rational design of small molecule inhibitors of nucleolin require sufficient quantities of the protein. Since cellular lev…

Prostate cancer (PCa) is the fifth leading cause of cancer-related deaths amongst men worldwide. Androgen deprivation therapy (ADT) in combination with radiation therapy (XRT) is the standard of care for high-risk localized PCa. Unfortunately, most patients become resistant to A…