Poly(lactide-co-glycolide) (PLG) biodegradable microparticles were evaluated as an oral delivery system for immunisation against equine influenza virus. Model particulates (fluorescent polystyrene and gold labelled polystyrene) were used to characterise the route and mechanism o…
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Personal profiling is a dynamic learning process designed to enable individuals to identify their strengths, needs and aspirations in order to set strategic and behavioural goals. This single-site case study seeks to explore undergraduate occupational therapy students' attitudes…
This study aimed to construct a database of 1500 newly diagnosed patients with epilepsy referred to the epilepsy unit at the Western Infirmary in Glasgow between 1982 and 2005. These patients commenced their first ever epilepsy treatment at the unit. The database included demogr…
Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder of the haemopoietic stem cell, defined by the Philadelphia chromosome (Ph) - the outcome of a balanced, reciprocal translocation between the long arms of chromosomes 9 and 22. The novel fusion oncogene gener…
Herein, two translational issues related to the development of cell therapy discoveries into therapeutic products, are addressed. Firstly, analysis of whether the manipulations required to transfer cells from cell culture conditions to a target tissue affect cellular characteris…
The aim of the research was to investigate the concepts of, and attitudes towards, people with physical disabilities held by occupational therapy (OT) students, so that a theory of professional attitudes and professional action could be developed. The research was building on pr…
Introduction: Kidney Cancer accounts for approximately 2% of all new cancer diagnoses in the UK each year. Patient survival has improved over the past few decades; however the mechanisms of this are yet to be fully elucidated. Hypoxia inducible factor isoforms, HIF-1 and HIF-2, …
The thesis describes a number of examples of the use of recently developed mass spectrometry experimental approaches to characterise biologically important mixtures. The recently introduced field of ambient ionisation mass spectrometry has been utilised in the rapid, sensitive, …
Background & Aim: Osteoarthritis (OA) sufferers frequently turn to complementary and alternative medicine (CAM), of which the most common are acupuncture and homeopathy, to improve manageability of their condition. However, there is little extant evidence of effectiveness for th…
As the incidence of type 2 diabetes rises exponentially in the early part of the 21st century, the global healthcare and financial burdens associated with this chronic condition rise in tandem. As such, it becomes increasingly important to characterise this disease further, and …
China is an emerging force in undertaking randomised clinical trials. The quality of trials from China may affect not only its own substantial population but also potentially contribute to health policy throughout the world. However, little is known about the quality of clinical…
Animal experiments have been the standard method to assess the safety of chemicals used in cosmetic products for decades. However, public opinion has continued to demand that in vivo hazard identification methods conducted on animals are replaced with alternative methods. Resear…
Bronchopulmonary dysplasia (BPD) is a neonatal disease affecting the lungs of premature infants. Prematurely born infants have under-developed lungs and require invasive ventilation technologies to provide sufficient oxygen for survival. Artificial ventilation is thought to exac…
Stroke is a major cause of disability worldwide, with many stroke survivors being at high risk of falling. Falling leads to an increasing amount of hospital admissions, placing substantial economic burden on health services. It has previously been shown that exercise programmes …
Warfarin is a challenging drug to dose accurately, especially during the initiation phase because of its narrow therapeutic range and large inter-individual variability. Therefore, the aim of this thesis was to investigate the use of pharmacogenetics and clinical data to improve…
In clinical trials, sirolimus (rapamycin, a macrocyclic lactone) has been shown to exhibit antitumor activity across a variety of human cancers by binding to and inhibiting the activation of the mammalian target of rapamycin (mTOR), thus preventing cell cycle progression from th…
Cyclic adenosine monophosphate (cAMP) is a second messenger signalling molecule that has been reported to exert beneficial effects within the vasculature and other physiological systems. cAMP produces its effects within the cell through two key downstream effector molecules: exc…
Breast Cancer Associated gene 2 (BCA2), is a little-studied E3 ligase that is overexpressed in 56% of all primary breast cancers and has been linked with increased cell proliferation and invasion in vitro. BCA2 has been implicated in EGFR degradation however there is conflicting…
Neisseria meningitides is a major cause of meningitis epidemics in sub-Saharan Africa. A promising broadly-protective vaccine approach is outer membrane particle-based vaccine comprising GMMA (Generalised Modules for Membrane Antigens). To better understand vaccine potential and…