Thesiss

Alzheimer's disease (AD) is the most common type of dementia associated with a progressive decline in cognitive function, amyloid plaque deposition and neurofibrillary tangle formation. Oligomeric forms of the amyloid-beta peptide (A-beta-o) are considered the initiating trigger…

Alzheimer’s disease (AD) is the leading cause of dementia but despite being identified over a century ago, current treatments remain limited. To date, no disease-modifying therapies are available. Soluble, intracellular forms of β-amyloid (Aβ), a protein associated with AD, have…