Alzheimer's disease (AD) is the most common type of dementia associated with a progressive decline in cognitive function, amyloid plaque deposition and neurofibrillary tangle formation. Oligomeric forms of the amyloid-beta peptide (A-beta-o) are considered the initiating trigger…
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Surface topography is known to be important in biomedical applications such as scaffolds for tissue regeneration and has been shown to affect wettability and cell behaviour. Traditionally, topographical effects such as surface texturing have been generated using methods such as …
TetratricoPeptide Repeats or TPRs are a class of repeat proteins made up of - helices. Each repeat contains 34 amino acids that form a helix-turn-helix motif and is stabilised by short range interactions creating a non-globular fold. Tandem arrays of these repeats form stable su…
Objectives: Orthopaedic and dental implants are prone to frequent infections. This can lead to detrimental and often irreversible outcomes for many patients. The objective of this study was to develop a novel system using zinc oxide nanoparticles (nZnO) as a coating material tha…
The number of clinical procedures performed in the USA using bone graft substitutes was estimated at 1.1 million in 2010 and is projected to reach 1.3 million in 2015. This increasing demand for bone graft substitutes is a result of an ever-ageing population coupled with recent …
A promising approach to overcome thrombus and neointima formation on vascular grafts is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. Surface topography of these implants is proven to enhance cell attachment and to reduce the inflam…
There has been much work into getting clear and precise images of bone growing within different osteoconductive and osteoinductive scaffolds for the aim of investigating and quantifying the effect the different grafts have on the bone that forms within the graft. Before the bone…
Within the medical community, there has been increasing interest in understanding material growth in biomaterials. Material growth is the capability of a biomaterial to gain or lose mass. This research interest is driven by the host of health implications and medical problems re…
Designing a biosensor capable of continuously monitoring blood glucose concentration in people with diabetes has been a major challenge for over three decades. In this work we attempt to develop a novel microspike based minimally invasive biosensor for this purpose. Also, as a p…