Intractable epilepsy that remains resistant to drug treatment is a significant public health problem with very few alternative therapeutic options besides surgery. The goal of this research is to investigate hypothesized mechanisms of epileptogenesis and to explore innovative tr…
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Physiological signals are at the core of understanding, diagnosing, and treating the human body. Those provide valuable insight into the internal function and state of systems within the anatomy. Depending on the system being observed, a physiological signal can either be a sour…
Improving the quality of healthcare during hospitalization and after discharging can be realized by identification of 30-day unplanned hospital readmission risk. Prior research suggests that a significant proportion of preventable hospital readmission is attributed to non-index …
Breast cancer is a significant health problem, not only in the United States but globally. In the last year, breast cancer was the second leading cause of cancer deaths in the United States. In addition, the incidence rates of invasive and in situ female breast cancer increased …
The structure of solid tumours is a major factor contributing to poor treatment outcomes because it can prevent therapeutics from reaching cancer cells. Nanoparticles are able to increase the accumulation of therapeutics in the tumour as a whole but are not able to deliver thera…
Nuclear reprocessing is a technique used to recover uranium and plutonium from used nuclear fuel for the purpose of manufacturing new fuel or atomic weapons and involves the production of radioactive wastes. Nuclear reprocessing overall can reduce the volume of radioactive waste…
Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) continue to be a significant global burden, disproportionately affecting low- and middle-income countries (LMICs). While much progress has been made in treating these epidemics, this has led to a rise in liver complication…
The current treatment methods in cancer are associated with toxicity in healthy tissues, partial therapeutic response, drug resistance and finally recurrence of the disease. The cancer drugs are challenged by non-specific binding, undesired toxicity in healthy cells, low therape…
Cancer is the third leading cause of death worldwide, accounting for almost 13% of all mortalities. In developed countries, when caught early, cancer is very treatable with high success rates for first line treatments. In fact, only about 10% of cancer-related deaths are due to …
This dissertation investigates and describes the concept of precision medicine from historical, conceptual, capital investment, industry strategic, regulatory oversight, and medicalization perspectives. The study examines the various current and ongoing challenges, impacts, assi…
Background Pregnancies following assisted reproductive technology (ART) are associated with various placental related complications, some of which may be predicted by biomarkers earlier on in the pregnancy. Meanwhile, biomarker profiles in ART pregnancies are altered as compared…
To ensure safe and high quality treatments for their patients, radiation oncology teams conduct pre-treatment plan evaluations as well as weekly chart checks which assess the machine treatment parameters, patient set-up instructions, prescriptions, and radiation dose distributio…
Background : Early mobility and ambulation of the extracorporeal membrane oxygenation (ECMO) patients has shown to decrease mechanical ventilation time, delirium, Intensive Care Unit (ICU) length of stay, and improve physical functioning. However, few ECMO centers use a protocol…
The shoulder is the most mobile joint in the human body, allowing for the execution of complex and athletic tasks. Unfortunately, such expansive mobility comes at a cost. The shoulder is prone to instability, or painful symptoms associated with increased humeral head translation…
Bu tez çalışmasında mekanik tasarımını önceki çalışmalarda gerçekleştirdiğimiz olan el rehabilitasyon dış iskelet robotunun veri güdümlü öngörülü kontrolü amaçlanmıştır. Ayrıca dış iskelet robotu rehabilitasyon amaçlı aktif ve pasif egzersiz süreçlerinde empedans kontrol algorit…
As big data processing and cloud computing continue to grow exponentially, more than 85% of global data traffic has remained within data centers. A significant part of communication in datacenters, including rack-to-rack, rack-to-server, and building-to-building, is based on sho…
Neuropsychological and physiological age-related changes in older adults directly affect safety and independence, especially with regards to balance and mobility. The rollator is commonly prescribed as part of a fall-prevention strategy to manage older adults’ fall risks, optimi…
Background: To date, little is known about epidemiology of schizophrenia (SCH),major depressive disorder (MDD), and bipolar disorder (BP) in agricultural areas ofChina.
The neuroelectronic interface is a fascinating and powerful tool for enabling direct electrochemical interaction with the central and peripheral nervous systems as a means to alleviate symptoms of debilitating neurological conditions. As the name implies, successful design and i…