Introdução: O uso de substâncias psicadélicas por parte do ser humano remonta há milhares de anos atrás, fazendo parte dos costumes de determinadas culturas indígenas, que utilizam os psicadélicos em contexto ritualístico, com fins religiosos e terapêuticos. Uma destas moléculas…
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The loss of control in amounts of drug consumed is a common trait experienced by persons living with drug addiction. The motivation of this dissertation is to further our understanding in the neural mechanisms that mediate consumption of drugs of abuse, to reveal targets for pha…
Background: Concussions are frequent injuries sustained by collegiate athletes. They are often underdiagnosed and may lack adequate treatment due to a lack of standardization in diagnosis and return to play guidelines. Current research suggests that there is an increased risk of…
The consequences of colonialism for Canadian Indigenous peoples are far-reaching, and cumulative, with vast disparities in health, healthcare, and high mortality rates. Decolonizing Indigenous health and wellbeing is long overdue, requiring an equal partnership between governmen…
One’s perception of the world is personal. Different people can experience the same sensory stimulus in myriad ways, and the same person can experience the same sensory stimulus differently across time. What factors cause sensory experiences to differ? While daunting, identifyin…
Biomarker discovery and statistical modeling reveals the brain activity that supports brain function and dysfunction. Detecting abnormal brain activity is critical for developing biomarkers of disease, elucidating disease mechanisms and evolution, and ultimately improving diseas…
Traumatic brain injury (TBI) is a significant public health concern as it is a leading cause of mortality, morbidity and disability in the United States. According to the World Health Organization, TBI is expected to become the third leading cause of death and disability in the …
Every year, over three million people sustain traumatic brain injuries (TBI). Traumatic brain injury refers to any injury to the brain resulting from force to the skull that can cause concussion, contusion, and diffuse injury to neurons, which can further cause severe neurologic…
Making accurate predictions is one of the most critical functions of the brain. Whether made by a monkey deciding where to forage, a deer deciding which way to run, or a wall-street broker deciding how to invest, decisions are informed by expectations about possible future outco…
2,3-Benzodiazepin-4-one (BDZ-11) derivatives are a special group of 2,3-benzodiazepine compounds. These compounds have been previously synthesized as AMPA receptor inhibitors, and they are also potential drugs for the treatment of various neurological diseases involving excessiv…
This thesis deals with the theory and design of a hemispherical antenna array circuit that is capable to operate in the intermediate zones. By doing that, this array can be used in Hyperthermia Treatment for Brain Cancer in which the aim is to noninvasively focus the fields at m…
This thesis is part of current research at Center for Intelligence Systems Research (CISR) at The George Washington University for developing new in-vehicle warning systems via Brain-Computer Interfaces (BCIs). The purpose of conducting this research is to contribute to the curr…
This thesis describes a new disease encompassing infantile-onset movement disorder (including severe parkinsonism and nonambulation), mood disturbance, autonomic instability, and developmental delay that was identified in eight cousins of a consanguineous Bedouin family in Saudi…
Neuronal nicotinic acetylcholine receptors (nAChRs) play a crucial role in a number of clinically relevant mental and neurological conditions, as well as autonomic and immune disorders. The development of subtype-selective ligands for nAChRs therefore, holds high potential for b…
In the present dissertation I tested the hypothesis that discontinuous hormone replacement paradigms that maintain endogenous-like hormone release profiles are more effective than constant release regimens at maintaining male sexual behavior (MSB) in castrated male hamsters. Fur…
Explosions are associated with more than 80% of the casualties in the Iraq and Afghanistan wars. Given the widespread use of thoracic protective armor, the most prevalent injury for combat personnel is blast-related traumatic brain injury (TBI). Almost 20% of veterans returning …
The cerebellum is an area of the brain that plays a crucial role in the learning of motor skills. This process involves climbing fibers, which provide teaching signals to Purkinje cells in the cerebellar cortex when perturbations occur during a movement. However, controversy has…
Blast injury has been coined the "signature injury of the Iraq war" resulting in a surge of interest in understanding and addressing the corresponding pathological sequelae. As modern warfare develops into a distinctly guerrilla style combat by smaller terrorist groups against l…
To study if there is any association of caffeine with mortality secondary to cardiovascular disease in survivors of myocardial infarction (MI) and stroke, we used the Third National Health and Nutrition Examination Survey and the Linked Mortality File. Out of 1083 survivors of s…