As the principal antigen-presenting cells to T cells, dendritic cells (DCs) have a key role in the balance of immunity and autoimmunity. They are essential in two major, converse roles - eliciting T cell immune responses to pathogenic material, and maintaining peripheral toleran…
In Plasmodium falciparum -infected children, the relationships between blood cell histopathology, blood plasma components, development of immunocompetence, and disease severity remain poorly understood. This investigation relates levels of the pro-inflammatory cytokines IFN-γ, I…
This thesis addressed several aspects of protective autoimmunity in the CNS under pathological and physiological conditions. My research findings are summarized below. Using a mouse model of retinal ganglion cell (RGC) loss induced by local injection of aggregated β-amyloid pept…