Turkey Coronavirus (TCV) is the causative agent of an acute, highly infectious enteritis of turkey poults. The S1 subunit of the spike glycoprotein of TCV is the major inducer of virus neutralizing antibodies. The long range goal of this work is to prevent TCV infection using va…
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Systemic and mucosal humoral immune responses to an experimental B. avium infection were evaluated by using an ELISA technique. The three isotypes of immunoglobulin, IgG, IgA and IgM, were detected in serum, tracheal washings and lacrimal secretions in response to an intra-nasal…
The imiquimod S-28828 induced high serum levels of type I IFN in turkeys after oral administration. Spleen, bone marrow and peripheral blood leukocytes produced IFN following in vitro stimulation with S-28828. High dose treatment of turkeys with S-28828 enhanced the mortality ra…
Monoclonal antibodies (mAbs) have been essential tools in the elucidation of the immune system of mammals, and their application to identify surface molecules on leukocytes have allowed important functions of these cell to be identified (such as receptors that bind antigens, lig…
In this dissertation, the effects of: (a) alcohol and dietary restriction of tyrosine/phenylalanine (tyr/phe) or methionine on natural killer (NK) cell activity, (b) tyr/phe deficiency on polyinosinic-polycytidylic acid (poly I:C) augmentation of NK cell reactivity, and (c) tyr/…
Immunological reagents were prepared and characterized for the development of analytical methodology in bioanalytical research. Monoclonal antibodies to glucose oxidase (E.C. 1.1.3.4) from Aspergillus niger were prepared with apoenzyme as the antigen. Five of these antibodies, a…
The immunity produced by Pasteurella multocida vaccination is not well-understood. A series of in vivo and in vitro tests was used to characterize the immunity induced by vaccination with an inactivated P. multocida bacterin. In vivo tests. Passive protection experiments demonst…
The major histocompatibility complex (MHC) is a chromosomal region whose gene products regulate the immune response and thus, disease resistance. Genetic variation in disease resistance among the turkey lines at the Ohio Agriculture Research and Development Center were reported …
The presence of a T-cell marker, Thy 1.2, on noninduced and vaccinia virus-induced hamster cytotoxic cells was studied utilizing a murine monoclonal anti-mouse Thy 1.2 antiserum ((alpha)-Thy 1.2) which detects a Thy 1.2 homologue on hamster T cells. In the hamster, (alpha)-Thy 1…
The final chapter of polio is not complete. But the task of adapting the polio infrastructure is upon us now. Polio eradication has been a shared global priority. The challenge before us lies in defining the next health priority to share. Actively listening to stakeholders revea…
The FAST-ELISA and modified Ritchie concentration technique were used in a comparative study assessing incidence of Schistosoma mansoni infection among children from Halaba, Egypt (HE), Kaundama, Malawi (KM), and Mtayangoma, Malawi (MM). FAST-ELISA had a sensitivity ranging from…