Thesiss

Antibiotic resistance is a growing public-health concern. Efforts to control the emergence and spread of resistance would benefit from an improved ability to forecast when and how it will evolve. To predict the evolution of resistance with accuracy, we must understand and integr…

The ability of populations to adapt depends on a complex suite of traits including mutation and recombination rates and functional constraints on genes subject to selection. How much selection can act on these traits to promote adaptability remains an open question. This dissert…

Human activity is causing climates to change more rapidly than at any time in the last 10,000 years. If populations of organisms are unable to effectively respond to changing environments, they will be at risk of extinction. In plants, two of the most important mechanisms of res…