A infeção por retrovírus contribui para o desenvolvimento de linfoma em gatos e, apesar de estar associada a uma menor sobrevida, os estudos mais recentes não apontam como um fator determinante na avaliação do prognóstico desses indivíduos. No entanto, estes estudos foram realiz…
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Avian metapneumovirus (aMPV) is an agricultural pathogen of great economic importance. The viral infection was first recognized in the 1970's in Africa, but it wasn't until 1996 that the first outbreak occurred in the United States and was officially diagnosed the following year…
Rotavirus diarrhea causes a disproportionate amount of the world's childhood mortality. Approximately 611,000 children die each year due to complications of rotavirus infections. In this study we evaluate rotavirus vaccination using four different methods. We look at the epidemi…
Background. The emergence of antibiotic resistant pathogens is increasing the proportion of infectious disease deaths globally and this burden is greatest in developing countries. Studies from developed countries have shown that animal agricultural antibiotic use, along with hum…
Introduction WHO malaria elimination targets require sustained and robust surveillance systems to identify difficult-to-diagnose, low-density malaria infections which threaten control efforts. The WHO 'T3: Test, Treat and Track' initiative further reinforces the importance of th…
Salmonella enterica serovar Typhimurium (S. Typhimurium) es una bacteria Gram negativo y un patógeno gastrointestinal de importancia mundial, ya que es uno de los principales agentes causantes de intoxicación alimentaria y de enfermedades invasivas no tifoideas, principalmente e…
Background: At the launching of a new drug, data are incomplete regarding its safety, due to limitations of clinical trials. Therefore, it is essential to collect and monitor postmarketing data on drug safety. Observational pharmacoepidemiological studies are one strategy to mon…
In Indonesia, although the number of human fatalities from avian influenza is the largest globally, human influenza A is not a priority. There have been no studies on influenza A's burden, its risk factors, and its geographical distribution in the community. This information is …
Complex nonlinear dynamical systems are frequently utilized and play a significant role in the study of natural science and many other fields. This thesis studies dynamical systems both theoretically and numerically with the help of machine learning, quantifying uncertainties in…
Lesser scaup ( Aythya affinis ; scaup) comprise 89% of the continental breeding population of scaup (greater, Aythya marila , and lesser combined) which has declined nearly 60% over the past 5 decades from an estimated 7.9 million in 1972 to a historical low of 3.2 million in 20…
The Somatology industry as a discipline involves close body contact, where the risk exists between the client and the therapist, as well as between clients. It is expected that in these personal treatments a good standard of hygiene and cleanliness of surfaces, implements, as we…
I aimed to provide Ontario’s public healthcare payers with an economic evaluation of fracture prevention strategies for HIV-positive men who take antiretroviral therapy (ART). When developing microsimulations models for this purpose, calibration is critical and computationally e…
A substantial amount of work has investigated the long-term consequences that adolescent intermittent ethanol (AIE) can have on adult physiology and behavior. Our laboratory has primarily investigated how ethanol evoked alterations in both peripheral and central inflammation may…
Background: Despite the potential to increase risk for acquisition of HIV and other sexually transmitted pathogens, the frequency with which men experience asymptomatic urethral inflammation is unknown. To better understand the full spectrum of perturbations to the male urethra,…
B cells are the central component of the humoral immune system and critical for long term immunity against all forms of pathogens. Antibodies represent one of the earliest lines of defense within the adaptive memory response and are the major effectors of vaccine mediated protec…
This dissertation consists of three essays: “The Effect of Women's Access to Free Health Care on Breastfeeding Practices: Evidence from Armenia” examines how women's decisions regarding breastfeeding respond to increased maternal access to medical care. Specifically, I examine t…
Background: Human Cytomegalovirus (HCMV) is ubiquitous and associated with chronic T cell activation, immunosenescence, and age-related co-morbidities including cardiovascular disease, Alzheimer's disease, and bacterial and viral pneumonia infections. Additionally, HCMV is a com…
This dissertation is composed of the projects I worked on that were able to be made into scientific papers. My projects centered primarily around viral RNAs and how they interact with host cell mRNAs coding for selenoprotein, and if these effects were negated or enhanced by the …
Primary Sjögren’s syndrome is an autoimmune disease, in which the immune system targets the exocrine glands. The disease is characterized by inflammation and dysfunction of the salivary and lacrimal glands, leading to dry eyes and mouth.