Brain aging is a poorly understood process widely understood to be a major causative factor in age-associated neurodegenerative diseases such as Alzheimer's disease (AD). Proteins are involved in brain aging and neurodegeneration in many ways, and their functions and dysfunction…
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Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a prevalence of approximately 1% children worldwide. ASD is characterized by deficits in social communication and interaction and the presence of restricted interests and repetitive behaviours. Genetic alterati…
Background: The emotional bond between humans and animals has strong historical roots and is of growing interest. According to the common notion of the "pet effect," many pet owners believe that living with a pet may improve their health and well-being. However, there are contra…
Mutations in the human and mouse Ostm1/Ostm1 gene result in the most severe form of autosomal recessive osteopetrosis, an inherited hematopoietic bone disorder. We isolated and characterized the Ostm1 gene responsible for the spontaneous murine osteopetrotic gl mutation and func…
Interest in improving children’s executive function (EF) skills through interventions is increasing and several approaches have been tested (Takacs & Kassai, 2019). However, there is a need to further focus on specific populations of students, such as young students. The foc…
Family history of alcohol use disorder (AUD) is frequently endorsed by chronic pain patients. Although individuals with a family history of AUD have demonstrated enhanced sensitivity to painful stimulation, we are not aware of any previous research that has examined clinically-r…
Concussions are complex injuries that affect the brain and body in many ways. Symptoms such as nausea, headaches, and difficulty balancing can ensue for long periods of time in some cases. Sensory reweighting is a system within the body that helps us balance; it includes the vis…
The advanced survival of the early premature infant (EPI) since the post-surfactant era has not many improved comorbidities. EPI comorbidities influence their lifelong health, social, and cognitive outcomes. EPIs often have immature and disorganized responses to stimuli during t…
I explore human experience through the lens of the natural world while calling attention to preservation and its changing role. Encrusted with crystals my work explores fossilized fragments of our everyday world that speak to our current place in time and our connection to the n…
A salient difference between artificial and biological neural networks is the complexity and diversity of individual units in the latter (Tasic et al., 2018). This remarkable diversity is present in the cellular and synaptic dynamics. In this study we focus on the role in learni…
The ketogenic diet has grown in popularity in the last decade as a weight loss tool. Research into the diet’s effects on the body have revealed a variety of other health benefits. The use of exogenous ketone supplements to confer the benefits of the diet without strict adherence…
The presence of and/or search for meaning has divergent and salient outcomes for individuals’ physical, mental, and emotional well-being. Although numerous domains of meaning have been examined, the literature on the meaning of sex is sparse and lacks a quantitative measure. In …
This paper is a reflective piece done to fulfil the requirements for the Master’s of Philosophy in Psychology of Counselling. The paper consists of two parts. Part one looks to provide background, context and rationale for four of the research papers I have completed for the pro…
This thesis examines the function of humour and parody in the work of five women: Ada Leverson (1862-1933), Beatrice Hastings (1879-1943), Katherine Mansfield (1888-1923), Cornelia Barns (1888- 1941), and Margaret Anderson (1886-1973). Its intention is to provide an insight into…
Occupational noise induced hearing loss (occupational NIHL) is one of the leading causes of permanent hearing impairments not only in developing countries since developed countries such as the US also have a large number of employees who are at risk of occupational NIHL. A numbe…
Insomnia is a risk factor for suicidal behavior including attempts and suicide. We investigated whether insomnia symptom severity predicted suicidality and suicide in an at-risk sample. The sample included deceased psychiatric patients seen at Weber Human Services since 2008 (N=…
Phantom Limb Pain (PLP) is commonly suffered by people with amputations and even though it has been studied for centuries, it remains a mysterious object of debate among researchers. For one thing, despite the vast number of proposed PLP treatments, no therapy has so far proved …
In many longitudinal epidemiological and clinical studies, it is routine to collect multiple repeated measures, as well as one or multiple time-to-event outcomes. The follow-ups are usually long enough to measure some aspects of the disease. It would be interesting and appropria…
Stress-related brain mechanisms, specifically HPA axis dysregulation and reductions in hippocampal volume, have long been associated with the pathology of major depressive disorder, especially within the context of a history of childhood maltreatment. However, investigations tha…