Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a prevalence of approximately 1% children worldwide. ASD is characterized by deficits in social communication and interaction and the presence of restricted interests and repetitive behaviours. Genetic alterati…
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Emerging implantable microdevices hold great promise for the treatment of patients with neurological conditions. These biomedical systems have been exploited as unconventional treatment for the conventionally untreatable patients. Recent progress in brain-machine-interface activ…
In this thesis we investigate the mechanisms underlying the generation of abnormal EEG rhythms in epilepsy, which is a crucial step towards better treatment of this disorder in the future. To this end, macroscopic scale mathematical models of the interactions between neuronal po…
Epilepsy is the most common chronic neurological condition in the UK; however, there is little research detailing children's experiences of living with epilepsy. More generally, only a small amount of research has explored siblings' experiences of having a brother or sister with…
Background: It is often considered that, following paediatric acquired brain injury (pABI) and epilepsy, higher-level cognitive deficits, such as prospective memory (PM), are impaired and may only become apparent over time when these abilities are expected to develop and mature …
People with learning disabilities constitute about 2% of the general population. Epilepsy is more prevalent among people with learning disabilities compared with the general population. Effective communication is central to the management of people with learning disabilities and…
Epilepsy is one of the most frequent neurological afflictions world-wide. Due to the vast complications with current treatment, there is a high demand for more effective and safer antiepileptic drugs. In this study, three novel series of para -substituted N-benzenesulfonamide en…
Intractable epilepsy that remains resistant to drug treatment is a significant public health problem with very few alternative therapeutic options besides surgery. The goal of this research is to investigate hypothesized mechanisms of epileptogenesis and to explore innovative tr…
Epileptic disorders manifest with seizures and interictal epileptiform discharges (IEDs). The hemodynamic and metabolic changes that accompany IEDs may be critical for epileptogenesis but they are poorly understood. This thesis aims to characterize such changes. Given the unpred…
Applying data mining techniques on medical databases which contain un-structured and semi-structured data is a challenging task. It is not only due to the complexity of such databases but also due to the characteristics of the medical domain. This thesis describes how multiple l…
Amaç: Bu çalışmanın amacı epilepsi cerrahisi geçirmemiş fokal kortikal displazili nöbet hastalarında lezyon yeri, kullanılan tedavi seçeneklerinin belirlenmesi, en çok tercih edilen farmakoterapi ajanının ve tedavi başarısının belirlenmesidir. Gereç ve Yöntem: Marmara Üniversite…
Developmental cortical malformations are a major cause of intractable seizures. Determining the location and timing of susceptibility for epileptiform activity is critical to identifying what mechanisms contribute to epileptogenesis in any model. Using the freeze lesion rat mode…
Epilepsy, one of the most common neurological disorders, affects roughly 1% of the world's population. Despite ongoing research and the development of new pharmacological treatments, a significant number of patients' seizures remain inadequately controlled. This short-coming ref…
Background: In 1999, an instrument was developed to assess quality of life (QoL) among adolescences with epilepsy. To our knowledge there is not a validated Spanish version of this questionnaire. There is a gap in the literature about QoL and epilepsy among speaking Spanish popu…
The ketogenic diet has grown in popularity in the last decade as a weight loss tool. Research into the diet’s effects on the body have revealed a variety of other health benefits. The use of exogenous ketone supplements to confer the benefits of the diet without strict adherence…
Introduction Although the relationship between mental disorders and epilepsy has been studied for several years there is a lack of systematization of knowledge in this area. People with epilepsy, particularly those who are refractory to pharmacological treatment, have a high pre…
Background: Epilepsy monitoring units (EMUs) provide a safe environment for forming a more illustrative understanding of the patient’s seizure disorder. Patients are admitted to EMUs usually for several days at a time. Upon admission, electroencephalogram (EEG) electrodes are pl…
Background: It has long been accepted that the environment we experience can impact our well-being; throughout recorded history, the greatest prevalence and severity of disease has been experienced by marginalized and underserved populations. However, the translation of such non…
Background: Despite the so-called "generalised" nature of many epileptic seizures, patient specific spatio-temporal properties have been shown using imaging data at the macroscopic level of the cortex. Previous computational models have failed to account for spatial heterogeneit…