Functioning of biological objects is not merely a problem of physics and chemistry; it is in essence a problem of the organization of control, which involves a huge amount of information processing. Statistical analysis of structural sequences of biological macromolecules: DNA a…
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Arsenic (As) is a well-known human carcinogen. However, it is a poor mutagen, as such it has been proposed that its carcinogenicity may stem from its ability to interfere with or impair epigenetic machinery. For my dissertation work I investigated the effect of arsenic exposure …
Amaç: Bu çalışmada sıçanlarda streptozotosin ile oluşturulan diyabet modelinde kardiyovasküler komplikasyonları etkileyebilecek miRNA'ların kalp dokusundaki ekspresyon düzeylerine bakılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda, 300-400 gr arasındaki ağırlıkta olan Spragu…
This dissertation has two parts: first describes the analysis of microbiomes of the lower respiratory tract of healthy and diseased chickens. The second describes the epigenetic landscape that determines the gene transcription levels in the erythroid differentiation model. Multi…
DNA methylation has been proposed as an epigenetic, evolutionary mechanism for acclimation, transgenerational plasticity, and local adaptation without changes in DNA sequence. In this thesis, I assess the highly targeted evolutionary nature of DNA methylation in Chinook salmon f…
Climate warming has been predicted to severely impact tropical biodiversity due to its effect on ectotherm metabolism, which increases exponentially with temperature. Many studies have shown that size is reduced in arthropods to compensate for the stress of increased temperature…
Trade-offs occur at every level of ecological organization and are sensitive to changing environments and sudden perturbations to systems. To study trade-offs, it is necessary to characterize the costs and benefits of traits under conditions of environmental change, however this…
Childhood growth has been a means of identifying systemic, material inequalities within populations. The plasticity of growth is responsive to multiple environmental factors, most notably adequate nutrition, but also psychosocial stress. Psychosocial stress can be a function of …
Epigenetic modifications play a critical role in numerous processes throughout the lifetime of an organism by influencing gene regulation. Responsive to both endogenous cues and external stimuli, epigenetic modifications are key mechanisms underlying phenotypic plasticity. Epige…
Embryonic development is complex, dynamic, and dependent on environmental factors. Mechanisms of sensing and integrating environmental stimuli are diverse, and understanding these mechanisms in extant species can elucidate how complex phenotypes emerge from genomic information e…
Human aging is accompanied by frailty, susceptibility to disease, decline in motor and cognitive functions, and overall decline in physiological function as well as day to day living. The current work presents genomic and epigenomics approaches for studying the complex phenotype…
Atherosclerosis, the forerunner of cardiovascular diseases, is regarded as the main cause of mortality, with an age-related rise in prevalence. It is defined as a chronic immune-mediated inflammatory illness that causes a pathological thickening of arterial walls, obstructing bl…
The deciduous teeth are assumed to be less variable than the later-forming permanent teeth. This may be due to greater exposure of the later-forming teeth to environmental effects. Research supports that the sexes may differ in their susceptibility to environmental effects durin…
Background: It has long been accepted that the environment we experience can impact our well-being; throughout recorded history, the greatest prevalence and severity of disease has been experienced by marginalized and underserved populations. However, the translation of such non…