Background: African Heritage (AH) men have a higher overall incidence, earlier age of onset, more clinically advanced and aggressive disease, higher incidence of metastases and mortality from prostate cancer (CaP) compared to Caucasian men. Biological and genetic factors relatin…
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Fungal infections cause an estimated 13 million life-threatening infections and 1.6 million deaths annually. The burden of invasive fungal infections (IFIs) reflects immunocompromise resulting from the rise in HIV/AIDS and iatrogenic immunosuppressive therapy. Cryptococcal menin…
The geochemical composition of thirty two (32) oil samples in the Central Sumatra Basin (CSB) were determined by gas chromatography (GC), gas chromatography coupled with mass spectrometry (GC-MS) and gas chromatography isotope ratio mass spectrometry (GC IR-MS). The carefully se…
Allergy is a disorder of the immune system caused by an immune response to otherwise harmless environmental allergens. Currently 20% of the US population is allergic and 90% of pediatric patients and 60% of adult patients with asthma have allergies. These percentages have increa…
Background. Sleep has been shown to be shorter and more disturbed in Alzheimer's caregivers compared to non-caregivers, presumably due to challenges associated with caregiving. Caring for a spouse with Alzheimer's disease has also been associated with increased risk for cardiova…
Currently the Department of Defense (DoD) does not use exposure biomarkers to measure environmental exposures to chemicals. Blood and urine exposure biomarkers for volatile organic compounds (VOC), selected heavy metals, depleted uranium (DU), and chemical warfare agents are cur…
The Caspian region and specifically the Apsheron peninsula of Azerbaijan is known to be polluted with a variety of environmental contaminants, making risk assessment difficult. The wetlands of Sumgayit contain particularly complex mixtures of contaminants. Flow cytometry and the…
Application of the sympagic diatom-produced, C25 highly branched isoprenoid (HBI) termed IP25 to paleo-sea ice reconstruction has confirmed its utility as a qualitative seasonal sea ice proxy. Combination of IP25 and a pelagic biomarker into the Phytoplankton-IP25 index (PIP25) …
Background: Diagnosis of acute coronary syndromes (ACS) in the Emergency Department (ED) is a topical and contentious issue. Current diagnostic techniques rely on hospital admission for troponin testing. Only a minority of those admitted prove to have ACS while unacceptable prop…
Primary Sjögren's syndrome (pSS) is a chronic disabling disorder affecting a substantial proportion of the general population. Clinical manifestations are heterogeneous and can be severe or life-threatening. Currently, no specific tests are available for diagnosis of pSS. Therap…
The relationship among oxidative stress, mitochondrial DNA integrity, and longevity continues to be without a general consensus. Here, we hypothesize that short- and long-lived birds, including the budgerigar (Melopsittacus undulatus), guineafowl (Numida meleagris), quail (Cortu…
Bone bruise lesions (BBL) are documented on MRIs diagnosing acute knee ligament injury (AKLI). Recent evidence has indicated that a majority of patients that sustain an AKLI, especially anterior cruciate ligament (ACL) knee injury, will develop post-traumatic osteoarthritis (PTO…
This body of work aims to evaluate the use of oral fluid and blood collection for monitoring measles vaccination coverage in low-income countries. It sought to answer two questions: Can biomarker surveillance be used to monitor measles immunity in a resource-poor setting? Is sur…
Gas flaring is an essential part of the oil and gas industry safety and waste management procedures; however, it presents a potential exposure to BTEX compounds, a group of Non-Methane Volatile Organic Compounds (NMVOC), within up to a 10-mile radius of the flare point. The phys…
The Sirt Basin is located in the north of Libya, bordered on the north by the Gulf of Sirt in the Mediterranean Sea. Sirt Shale is dark-brown to black laminated organic rich shale containing abundant foraminifera, deposited during Maastrichtian to lowermost Campanian. The sample…
Lung cancer is the leading cause of cancer deaths in the US, in part due to poor diagnosis. Prognosis can be improved, if detected at an early stage. The objective of this study was to use the metabolomic approach to investigate early potential biomarkers for lung cancer. Golden…
Medical diagnostics contributes a large portion of both time and resources in the timeline of medical treatment. Point-of-Care diagnostics offers the ability to diagnose illness or the risk of certain conditions rapidly and at low cost, affording the opportunity of implementing …
Background Pregnancies following assisted reproductive technology (ART) are associated with various placental related complications, some of which may be predicted by biomarkers earlier on in the pregnancy. Meanwhile, biomarker profiles in ART pregnancies are altered as compared…
With no cure or disease-modifying treatment for Alzheimer’s Disease (A.D.) and high-profile drug failures in recent clinical trials, there remains a global commitment to advancing dementia research and therapeutic innovation. As new clinical trials and research collaborations fo…