Thesiss

In plants, genetic diversity is important for species adaptation in nature and for crop improvement through breeding. For decades, genetic diversity was measured at the nucleotide and gene level. With the abundance of whole genome sequences and chromosome level genome assemblies…

Melanoma accounts for the majority of the mortality from all types of skin cancers. Five to ten percent of the cases are familial melanoma, yet more than 50% of the melanoma families cannot be explained by established susceptibility genes. By understanding the genetics behind un…

Human aging is accompanied by frailty, susceptibility to disease, decline in motor and cognitive functions, and overall decline in physiological function as well as day to day living. The current work presents genomic and epigenomics approaches for studying the complex phenotype…

In this thesis I studied cause and effect of Cyto Nuclear Incompatibility (CNI) induced speciation in plants. By combining comparative genomics, phylogenetics and bioinformatics with large scale crossing experiments I was able to infer part of the genetic machinery underlying CN…