Melanoma accounts for the majority of the mortality from all types of skin cancers. Five to ten percent of the cases are familial melanoma, yet more than 50% of the melanoma families cannot be explained by established susceptibility genes. By understanding the genetics behind un…
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We are interested in studying the roles of serine/threonine kinases from Drosophila melanogaster. Drosophila has been studied as a genetic system for over a century. Thus numerous approaches are available to generate, maintain, and manipulate genetic mutants (Ashburner, 1989; Fl…
Salmonella enterica serovar Typhimurium (S. Typhimurium) es una bacteria Gram negativo y un patógeno gastrointestinal de importancia mundial, ya que es uno de los principales agentes causantes de intoxicación alimentaria y de enfermedades invasivas no tifoideas, principalmente e…
Splicing factors bind, in most cases, to a degenerate motif in the pre-mRNA of the target gene and either recruit or repel the spliceosome to/from nearby splice sites. Many splicing factors possess RNA-independent functions, such as protein-protein interactions in cellular compl…
Cysteine proteases cathepsins are lysosomal enzymes that regulate numerous lysosomal functions but were also appreciated for their extra-lysosomal activities and their contribution to various pathologic conditions. Given the diversity in cathepsin function, we set out to explore…
The transcriptional co-activator PGC-1a is widely accepted as the “master regulator” of mitochondrial biogenesis – an increase in mitochondrial content – and much research has been devoted to understanding PGC-1a’s role in mitochondrial remodeling. However, several studies have …
Gangliosides are sialic acid containing biomolecules and perform important functions by locating on cell membranes. Their catabolism regulated by sialidases while their synthesis was performed by glycosyltransferases. Neu3 reacts with gangliosides on plasma-membrane and acts in …
Amaç: Son yıllarda yapılan çalışmalar Myrtus Communis L. (MC) ekstraktının antioksidan ve antidiyabetik özelliklerini ortaya koymaktadır. Bu çalışmadaki hedefimiz bu ekstraktın yüksek yağlı diyet (YYD) ile beslenen sıçanların pankreası üzerinde etkilerini ortaya koyabilmektir. G…
Aging is a degenerative process characterized by a decline in physiological functions and cellular activities. Environmental and pharmacological interventions affecting longevity pathways have been extensively studied in model organisms. This study investigated the effect of chr…
Colorectal cancer (CRC) is the third leading cause of death from cancer in both men andwomen in the Western world. Improved screening efforts, surveillance, and treatment havereduced CRC mortality in older patients. However, the incidence is increasing in young adults,even in th…
Evolution during treatment is a significant clinical problem that leads to treatment failure, resistance, and disease progression in many solid tumors, including breast cancer. Through analysis of clinical tissue samples and using a combination of established genomic techniques,…