Thesiss

The design of new, improved NO-donor drugs is an important pharmacological objective due to the biological importance of nitric oxide. N-Hydroxyguanidines represent a useful class of NO donors where the mechanism of action is based on the biosynthetic pathway for NO. Thirty new …

The transcriptional co-activator PGC-1a is widely accepted as the “master regulator” of mitochondrial biogenesis – an increase in mitochondrial content – and much research has been devoted to understanding PGC-1a’s role in mitochondrial remodeling. However, several studies have …

This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five specie…

Reef-building corals globally face an increasing assortment of existential threats, ranging from disease outbreaks to intensifying climate change, resulting in wide-scale population declines. Until recently, our understanding of coral evolutionary genetics, as well as any potent…

The field of plant natural product (NP) discovery has changed substantially since the isolation of morphine from opium poppy in 1806. The largest of these changes came in the last decade with the integration of computational genomics into the field, which resulted in the develop…