Introdução : A espiritualidade é o aspeto da humanidade que se refere à forma como os indivíduos procuram e expressam sentido e propósito e está frequentemente relacionada com o significante ou sagrado. A espiritualidade torna-se particularmente importante nos cuidados em fim de…
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Introdução: Atualmente o Cancro Colorretal é uma das neoplasias mais diagnosticadas nos países desenvolvidos. Na Europa, acomete 17 em cada 100 000 habitantes. Apresenta baixa incidência abaixo dos 50 anos de idade e é mais frequente em homens do que mulheres. Os principais fato…
O Cancro oral é um desafio na prática clínica, sendo com frequência diagnosticado em estadios tardios. Dado o seu caráter localmente invasivo e multifocal, pode requerer abordagens terapêuticas com graves danos funcionais e estéticos para o doente. Por sua vez, a lesões prémalig…
Complementary and alternative medicine (CAM) is a term applied to treatments that are not part of conventional medicine, and in some cases, they may be used instead of conventional medicine. One national study and several international studies have identified the frequency of CM…
This project sought to locate articles containing data on radiation dosimetry in outer space, to use those data to create a Location Exposure Matrix (LEM) for equivalent radiation doses in extraterrestrial environments, and then apply the LEM to the study of US astronaut mortali…
More breast cancers are diagnosed in the left breast than the right. The ratio (l/r) is called the laterality ratio. We analyzed 1.2 million cases of breast cancer diagnosed in the US between 1973 and 2010 and recorded by the Surveillance, Epidemiology, and End Results (SEER) pr…
The need for chemotherapy treatments at outpatient settings have significantly increased in the past several years. Ambulatory Infusion Centers are encountering difficulties in matching individual patient needs and infusion chair availability due to the high variability in chemo…
Aflatoxin B1 (AFB1) is a potent dietary hepatocarcinogen and may be a lung carcinogen when inhaled. To study the relative ability of lung and liver to metabolize AFB1, a susceptible (Swiss-Webster rat) and resistant species (Syrian golden hamster) were pretreated with inducing a…
This dissertation project was initiated as part of an investigation directed toward the discovery of new cancer chemopreventive agents from plants, and two species were chosen for detailed study. The petroleum ether and ethyl acetate-soluble extracts of the stem bark of Pongamia…
The aim of this study was to determine cancer mortality rates for the United Arab Emirates (UAE) and to create an atlas of cancer mortality for the UAE. This atlas is the first of its kind in the Gulf country and the Middle East. Death certificates were reviewed for a period fro…
Purpose. The aims of this study are to develop and examine the psychometric properties of a 48-item The Cancer Knowledge, Attitudes, & Beliefs Scale (C-KABS), to evaluate the Cancer Screening Action Model (C-SAM), and to generate knowledge regarding the attributes of cancer scre…
To establish comprehensive pharmacology of P2X₇ receptors, membrane current recording, intracellular calcium transient recording and ethidium bromide uptake were carried out to examine several selective (A-740003, A- 438079) and non-selective (suramin) P2X₇ antagonists across ma…
The unfolded protein response (UPR) is a complex signalling pathway activated in response to endoplasmic reticulum stress. In recent years, the UPR has been implicated in cancer and chemosensitivity, particularly in solid tumours. This thesis investigated the potential value of …
Activating mutations of the kras proto-oncogene are found in more than 90% of human pancreatic ductal adenocarcinoma (PDAC) and can result in increased activity of the NF-κB pathway, leading to constitutive production of proinflammatory cytokines such as TNF-α. Pancreatic cancer…
Introduction: The epithelial-specific integrin αvβ6 usually is undetectable on normal, adult, human tissue but is upregulated during tissue re-modelling and carcinogenesis. Objective: To develop and characterise agents for targeting αvβ6 in cancer. Methods: A series of peptides …
This thesis is the culmination of five years of communication design research (2006 – 2010) on a specific area of healthcare—breast cancer detection and screening. It is a project-‐based doctoral work, underpinned by a practice-‐led research journey of a graphic designer. The …
This thesis explores the difficulties of talking about cancer. Conversational interviews with 17 people diagnosed with cancer are analysed from the perspective of discursive psychology which treats accounts and the description of events as discourse practices and categories. Can…
The Notch pathway is evolutionary conserved and involved in several key cellular functions that ensure tissue homeostasis in the adult organism. Such an important pathway requires a fine regulation which was found to be orchestrated by different regulatory mechanisms. Our group …