In plants, genetic diversity is important for species adaptation in nature and for crop improvement through breeding. For decades, genetic diversity was measured at the nucleotide and gene level. With the abundance of whole genome sequences and chromosome level genome assemblies…
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Discutiu-se nas últimas décadas qual o regime jurídico a aplicar aos recursos genéticos marinhos em áreas além da jurisdição nacional. Em abril de 2019 decorreu a segunda sessão da Conferência Intergovernamental orientada para a redação de um novo instrumento internacional vincu…
One of the major limitations of aquaculture has been the inefficient digestion of phytate-bound phosphorus in plant-based diets. The enzyme phytase has been found to degrade phytate into a form that can be utilized by non-ruminant animals. The goal of this research was to produc…
Terpenes are one of the three most common metabolites in nature, derived from isoprene units to form the carbon skeleton building block of various terpene classes. Terpenes which are chemically modified, such as by isomerisation or oxidation, are also called terpenoids and are i…
Coding theory has several applications in Genetics and Bioengineering. This thesis concentrates on a specific application from Computational Biology. This concerns the construction of new DNA codes which satisfy certain combinatorial constraints, using an alphabet of four symbol…
Cell proliferation is the process of increasing cell number in a multicellular organism. In literature, there are numerous proteins and non-coding RNAs reported as regulators of cell proliferation, yet, many of others are waiting to be explored. Unravelling the mechanism behind …
Westerners have long imagined, represented, and treated islands around the globe as “natural laboratories” given their perceived geographic isolation. It was on islands that colonizers first conducted “experiments” in imperial expansion via the establishment of plantation econom…
In this dissertation the question addressed is the ethical protocol that should be used when enhanced, post or transhumans present themselves as patients to hospitals, or as subjects for scientific research. With the advent of the birth of four children who were genetically engi…
The development and adoption of gene therapy as a new therapeutic modality represents a fundamentally new approach to treating diseases by directly modifying human genetic material. No longer the speculations of visionary scientists and science fiction authors, gene therapy make…
Synthetic biology and technological advances are often framed in film through a narrative lens of fear and misunderstanding. This has been the case in literature and media dating back to Mary Shelley’s 1818 novel, Frankenstein. This novel is often cited as the first science fict…
In this thesis I studied cause and effect of Cyto Nuclear Incompatibility (CNI) induced speciation in plants. By combining comparative genomics, phylogenetics and bioinformatics with large scale crossing experiments I was able to infer part of the genetic machinery underlying CN…