A atresia biliar é a causa mais comum de colangiopatia obstrutiva infantil e a indicação mais frequente para transplante hepático na população pediátrica. É uma patologia que se inicia exclusivamente na infância e que se caracteriza por uma obstrução de parte ou da totalidade da…
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In plants, genetic diversity is important for species adaptation in nature and for crop improvement through breeding. For decades, genetic diversity was measured at the nucleotide and gene level. With the abundance of whole genome sequences and chromosome level genome assemblies…
Cancer is a genetic disease. The cancer cells evolve clonally through changes of their genome, gaining malignant characteristics. In hereditary cancer syndromes, a genetic aberration which puts the cells one step closer to being malignant is inherited and present throughout whol…
Predecir el precio del cobre no es una tarea fácil. Productores, consumidores, inversionistas e incluso algunos gobiernos deben enfrentarse a este tema. Existen muchas fuentes de información y diferentes modelos para completarla, sin embargo, no hay un consenso claro de cuándo e…
Heat stress causes major losses to cotton seed and lint yield. Introduction of heat stress tolerance to Arkansas cotton varieties is highly desirable. However, very little is known about the molecular basis of heat stress tolerance in cotton. The present study attempted to ident…
Escherichia coli synthesizes and secretes the iron-chelating siderophore enterobactin under conditions of iron stress. Six genes for enterobactin biosynthesis, entABCDEF, five genes for the transport of ferrienterobactin, fepABCDG, and the gene for ferrienterobactin hydrolysis, …
The arabinose regulon was the first system to be identified under positive regulation. araBAD, the operon expressing the catabolic enzymes for L-arabinose, is under both positive and negative control whereas araC, the regulator gene, is under negative control only. Both promoter…
The elucidation of molecular function of proteins encoded by genes is a major challenge in biology today. Genes regulate the amount of proteins (enzymes) needed to catalyse a metabolic reaction. There are several works on either the modelling of gene expression or metabolic netw…
The analysis of single-cell data creates the opportunity to examine the temporal dynamics of complex biological processes where the generation of time course experiments is challenging or technically impossible. One popular approach is to learn a lower dimensional manifold or tr…
Regeneration, the replacement of lost or damaged body parts, and biomineralisation, the biologically controlled formation of minerals, are important and widespread abilities in the animal kingdom. Both phenomena have a complex evolutionary history; thus their study benefits from…
The epidermal differentiation complex (EDC) encodes co-ordinately regulated genes critically involved in epidermal differentiation, however knowledge of the molecular mechanisms involved in co-ordinating EDC gene expression is limited. Recent findings indicate p63 dependent chan…
Cancer is a serious threat to human health and is now one of major causes of death worldwide. However, the complexity of the cancer makes the development of new and specific diagnostic tools particularly challenging. A number of different strategies have been developed for bioma…
The evolution of a gene’s expression profile is commonly assumed to be independent of its genomic neighborhood. This is, however, in contrast to what we know about the lack of autonomy between expression of neighboring genes in extant taxa. Indeed, in all eukaryotic genomes, gen…
Zooplankton are the major primary consumers in pelagic ecosystems, providing the principal pathway for energy transfer from primary production to higher trophic levels. The marine copepod Calanus finmarchicus is an important component of the pelagic food web in the North Atlanti…
Some upstream open reading frames (uORFs) regulate gene expression (i.e. they are functional) and can play key roles in keeping organisms healthy. However, how uORFs are involved in gene regulation is not het fully understood. In order to get a complete view of how uORFs are inv…
Fish meal (FM) and fish oil (FO) have traditionally been central in aquaculture feed formulation but the finite global supply situation limiting future use along with issues of contaminant levels in these feed ingredients have become critical issues. The objectives of the presen…
Microarray technology has revolutionized the field of molecular biology by offering an efficient and cost effective platform for the simultaneous quantification of thousands of genes or even entire genomes in a single experiment. Unlike southern blotting, which is restricted to …
In the present study, muscle growth and flesh quality have been investigated from both commercially farmed Atlantic halibut (Hippoglossus hippoglossus) (Aga marine AS, Norway)and halibut obtained from small-scale trials at Mørkvedbukta Research Station (Bodø University College, …