B lineage cells regulate BAFF-R expression to utilize and manipulate the powerful BAFF/BAFF-R survival and proliferation axis. To elaborate B cells’ mechanisms of receptor regulation within the BAFF/BAFF-R axis, this work explored physiological regulation in normal B cells as we…
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Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of the malignancy adult T-cell leukemia (ATL), a malignancy for which there is no effective therapy. Drugs targeting the viral enzyme integrase have been in use for several years as part of the treatment regimen …
The cancer stem cell hypothesis proposes that a minority of transformed stem cells, with acquired self-renewal properties, are the source of tumor initiation and progression. This notion has been around for over a century and case studies have been reported for hematological mal…
The canonical Wnt signaling pathway is pathogenic in a variety of cancers. Expression of the Wnt pathway transcription factor and target gene lymphoid enhancer binding factor 1 (LEF-1) in chronic lymphocytic leukemia (CLL) suggested that the Wnt signaling pathway has a role in t…
Background: A growing body of evidence suggests that a number of perinatal factors may increase the risk of acute lymphocytic leukemia (ALL), the most common childhood cancer. Objective: To better understand perinatal factors associated with ALL with particular attention to oxyg…