Thesiss

The canonical Wnt signaling pathway is pathogenic in a variety of cancers. Expression of the Wnt pathway transcription factor and target gene lymphoid enhancer binding factor 1 (LEF-1) in chronic lymphocytic leukemia (CLL) suggested that the Wnt signaling pathway has a role in t…

The development of complex metazoans depends on the integration of a handful of signalling pathways that eventually modulate precise patterns of gene expression. The fact that just a few pathways are involved in the generation of such complexity in different organisms, suggests …