Thesiss

The Notch pathway is evolutionary conserved and involved in several key cellular functions that ensure tissue homeostasis in the adult organism. Such an important pathway requires a fine regulation which was found to be orchestrated by different regulatory mechanisms. Our group …

The differentiation of mesenchymal stem cells (MSCs) to endothelium is a critical but poorly understood feature of tissue vascularisation and considerable scepticism still remains surrounding this important differentiation event. Defining features of endothelial cells (ECs) are …

The development of complex metazoans depends on the integration of a handful of signalling pathways that eventually modulate precise patterns of gene expression. The fact that just a few pathways are involved in the generation of such complexity in different organisms, suggests …