MicroRNAs play an important role in biological regulation. Recently miR-34a has been reported to regulate tumour cell cycle progression and apoptosis. However, the functional role of miR-34a in smooth muscle cell (SMC) differentiation from stem cells is yet unclear. Main objecti…
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Insufficient maternal folate during pregnancy increases the risk of the baby being small for gestational age (SGA). Studies in teenagers, a population vulnerable to folate deficiency and SGA birth, have shown that low maternal folate status is associated with impaired placental …
The cancer stem cell hypothesis proposes that a minority of transformed stem cells, with acquired self-renewal properties, are the source of tumor initiation and progression. This notion has been around for over a century and case studies have been reported for hematological mal…
Previous studies in our group revealed the existence of truncated forms of T cell receptor β (TCRβ) mRNA in mesenchymal cells. The expression of truncated TCRβ mRNA was not restricted to mesenchyme. Indeed, such transcripts were found also in the thymus. The present study was ai…
Over the past 30 years, mammalian cell culture has enabled the production of recombinant protein therapeutics for treatment of a broad range of debilitating or life-threatening diseases. Continual improvements in cell and process engineering have facilitated the attainment of on…
Consolidation of nascent memory into long lasting forms involves synaptic plasticity. Even in the relatively simple brain of Drosophila , memory evolves in neural location and temporal stability. While distinct biochemical mechanisms likely act on the neural pathways that acquir…
microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation miRNAs are single-stranded RNAs of ∼22 nucleotides, which repress protein expression at a post-transcriptional level. Mechanistically, base pairing of the miRNA 'seed' re…