Thesiss

The analysis of single-cell data creates the opportunity to examine the temporal dynamics of complex biological processes where the generation of time course experiments is challenging or technically impossible. One popular approach is to learn a lower dimensional manifold or tr…

Alteration in the tone of pulmonary arteries may lead to disease such as pulmonary hypertension often associated with major cardiac complications. This dysfunction is partly in the pulmonary arterial smooth muscle cells (PASMCs) where the excitation-contraction coupling is modif…

This thesis comprises three sections of research in statistical genomics and computational biology. Chapter 1 and Chapter 2 describe two statistical methods for multi-omics inference from single cell transcriptome, representing the theme of this thesis. Chapter 3 describes a sid…