There is a need for tissue engineers to recreate extracellular matrix that mimics the highly organized extracellular structures as seen in vivo. In a previous study in the extracellular matrix engineering research laboratory (EMERL), a micromechanical system was used to create s…
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By employing a bioarchaeological perspective, this dissertation addresses how quotidian acts are altered during and as a consequence of sociopolitical change. Specifically, variation in day-to-day activities associated with the transition from the New Kingdom to the Napatan Peri…
The rapid progression of high-grade brain tumors is related to diffuse infiltration of single tumor cells into the surrounding brain parenchyma, a process that involves aberrant interactions between tumor cells and the extracellular matrix (ECM). Tremendous effort has been devot…
Proton nuclear magnetic resonance \sp1H NMR was used to investigate the entire signal from excised lung tissue. The free induction decay signal contained a motionally restricted component which decayed in a few 10's of μ s and a mobile component which persisted about 10 ms or lo…
NQT-SHE cells derived from Syrian hamster embryo (SHE) fibroblasts transformed by 4-nitroquinoline-1-oxide synthesize two modified α2(I) subunits of type I collagen designated as N-33 and N-50 (N-collagens). The N-collagens migrate more slowly than the normal α2(I) chain during …
Abdominal surgery itself, and implants used in abdominal wall reconstruction, are associated with intra-abdominal inflammation that can go on to cause complications such as adhesions, fistulae or failure of the implant. The pathophysiology of these complications is not fully und…
In the present study, muscle growth and flesh quality have been investigated from both commercially farmed Atlantic halibut (Hippoglossus hippoglossus) (Aga marine AS, Norway)and halibut obtained from small-scale trials at Mørkvedbukta Research Station (Bodø University College, …
Bone is an interpenetrating inorganic/organic composite that consists of mineralized collagen fibrils, which is hierarchically organized into various structures. The structure of mineralized collagen fibril, in which nano-crystals of hydroxyapatite are embedded within the collag…
Extracellular matrix (ECM) is a key component and regulator of many biological tissues. Several cardiovascular pathologies are associated with significant changes in the composition of the matrix. Better understanding of these pathologies and the physiological phenomenon behind …
Collagen is the most abundant protein in mammals and has special mechanical behavior that enables it to play an important role in the structural integrity of many tissues, e.g., skin, tendon, bone, cartilage and blood vessels. The mechanical properties of collagen are governed b…