This study was undertaken to develop and evaluate various dermatological formulations with optimum drug release and clinical efficacy. Formulations containing 0.5% of Clotrimazole were developed using HPMC gel, cationic and non-ionic emulsion based vehicles. Penetration enhancer…
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The number of immigrants entering the United States has increased dramatically in the past 30 years, but minorities and ethnic groups are underrepresented in research studies. This study examined first- and second-generation Arab American immigrants in Dearborn, Michigan, using …
Previously, the high-density lipoprotein (HDL) mimicking porphyrin-lipoprotein (PLP) nanoparticle was found to accumulate more in tumours compared to their non-cancerous counterparts in several clinically relevant animal models. PLP demonstrates stability in blood circulation an…
Rodent-borne hantaviruses are RNA viruses found throughout the world that can cause deadly diseases in humans. These viruses can be classified into two clades, depending on the geographical distribution of their natural hosts and zoonotic human illness. Those primarily located i…
Amaç: Çalışmamızdaki amaç; benzo (a) piren (BaP), dimetil benz (a) antrasen (DMBA) ve n-metil-n-nitrozüre (MNU)‘nin zebra balıklarındaki başta karsinojenik olmak üzere olası etkilerinin incelenmesidir. Gereç ve Yöntem: Zebra balığı embriyoları 96.saat sonunda BaP, DMBA ve MNU’ya…
Amaç: Kanser, tüm dünyada her altı ölümün birinden sorumlu olup, kardiyovasküler hastalıklardan sonra ikinci en yaygın ölüm sebebidir. Çoklu direnç gelişimi ile birlikte enfeksiyonların bilinen antibiyotiklerle tedavisinin güçleşmesi, virüslerin hızlı mutasyonu ile kullanılan an…
This thesis presents three statistical projects on clinical trial design, climate projections and air pollution assessment. The first project is related to clinical trial phase I/II design. The objective in phase I/II is to find the optimal dose for treating patients. However, t…
Amaç: GheOP3S aracı (Community Ghent Older People’s Prescriptions Community Pharmacy Screening) kullanarak yaşlı hastaların ilaçlarını incelemek ve potansiyel uygunsuz reçeteleme varlığı ile ilaç rejim karmaşıklığı arasındaki ilişkiyi tespit etmek. Gereç ve Yöntem: Bu kesitsel ç…
Introducción: El síndrome metabólico (MetS) es un conjunto de trastornos que incluyen a la obesidad visceral o abdominal, la hipertensión arterial, la hipertrigliceridemia, el colesterol HDL bajo y la hiperglicemia. Ante la presencia de tres o más de los cinco criterios definido…
Introduction: Type 1 diabetes is an autoimmune condition that results in the inability of the pancreas to produce insulin. The mainstay of treatment for this disease is administration of exogenous insulin. Adherence to this therapy is vital in avoiding both life-threatening shor…
Erythropoietin (EPO) is a glycoprotein hormone secreted by the kidney to regulate erythropoiesis. It stimulates red blood cell (RBC) production by promoting the survival, proliferation, and differentiation of erythroid precursor cells in the bone marrow. Recombinant human erythr…
Correct diagnosis of disease is essential in the effort to save and improve lives. Point of care (POC) diagnostics are in-vitro tests that assist in patient diagnosis and can be used at the location of patient care. POC diagnostics are easy to use and provide near-instant readou…
Real world data (RWD), data from various sources other than clinical trials, is increasingly being integrated into the research setting. In particular, electronic health records (EHRs), which serve as a clinical record to document a patient’s medical history as well as support a…
Peptidyl macrocycles are a compound class with a rich clinical history and great potential for drugging biological targets by mediating protein-protein interactions. Methods to forge S-S disulfide bonds largely rely on the oxidation of dithiol containing substrates. We have deve…
Type 2 diabetes (hereafter, diabetes) and prediabetes are very common in older adults and constitute a great health concern for this population. The objective of this project is to investigate the impact of prediabetes and diabetes on health and survival among older adults, and …
Breast cancer is one of the leading causes of cancer death in women. According to American Cancer Society, breast cancer is estimated to account for 30% of all newly-diagnosed cancers in women, and 15% of cancer-related deaths. A significant number of women use complementary and…
Increased exposure to antibiotics has led to the dissemination of genes conferring resistance to antimicrobial metabolites throughout human microbiomes globally via horizontal gene transfer (HGT). This has resulted in the emergence of new resistant strains leading to a rising ep…
Alcohol use disorder and alcohol related phenotypes are genetically influenced, complex traits. Complex traits have proved challenging for connecting genotype to phenotype because they arise from a number of genetic factors capable of interacting with each other and the environm…