Thesiss

Replication protein A (RPA) is known to interact with guanine- (G-) rich sequences that adopt G-Quadruplex (GQ) structures. Most studies reported in the literature were performed on GQ formed by homogeneous sequences, such as the human telomeric repeat, and RPA's ability to unfo…

The research presented in this thesis focuses on the molecular design of an oxidation-sensitive nanocarrier and its enzyme conjugate with a view of their application in the field of biomaterials. I have polarised our attention on a specific class of polymers, the polysulfides, f…

Single-stranded DNA binding proteins (SSB) bind to single-stranded DNA (ssDNA) that is generated by molecular machines such as helicases and polymerases. SSBs play crucial roles in DNA translation, replication and repair and their importance is demonstrated by their inclusion ac…

Humans have exploited small molecule natural products have exploited throughout history. Recently, advances in chemistry and biology have led to an explosion in drug development, revolutionizing the treatment of infectious diseases, cancer, and other ailments. However, current t…