Thesiss

This dissertation describes the efforts that culminated in the first total synthesis of saudin, 1, a novel hypoglycemic agent of Saudi Arabian origin.* Racemic saudin was prepared in 15 steps and 5% overall yield starting from simple precursors. The key step in the synthesis was…

The plant genus Aglaia, native to the tropical rain forests of Indonesia and Malaysia, is the source of a unique group of densely functionalized natural products named the rocaglamides. This family of natural products may be divided into three distinct members. The rocaglamides …

Peptidyl macrocycles are a compound class with a rich clinical history and great potential for drugging biological targets by mediating protein-protein interactions. Methods to forge S-S disulfide bonds largely rely on the oxidation of dithiol containing substrates. We have deve…