Recent developments of more effective Multiple Sclerosis (MS) medications with severe side-effect profiles mean that patients with MS must recall and comprehend highly complex risk-benefit treatment information. Yet studies have shown reduced risk awareness in people with MS, wh…
"18" Result
Sort By:
Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system and is considered to be a T-cell mediated autoimmune disease. The “ideal” method in treating MS would be an antigen-specific therapy that does not require generalized immunosuppression. To…
An endophenotype is a concept that allows the description of complex diseases with genetic and environmental contributions,enabling the identification of an at risk population. I aim to describe an endophenotypic gradient between healthy controls, siblings of people with MS and …
Multiple Sclerosis (MS) is a chronic neurological condition, which affects around 2.5 million people worldwide. At a time when there is yet no recognised cure, it is imperative that MS patients learn to cope and adjust well to living with the illness. However, research has found…
The studies reported examined the feasibility of assessing QoL, and the factors that influence QoL perceptions, in persons with late-stage neurodegenerative illness. Residents with a range of diagnoses from the Royal Hospital for Neuro-disability, Putney, took part in five studi…
Multiple sclerosis (MS) is an autoimmune mediated degenerative disease of the central nervous system that is characterized by focal neurological deficits that are marked by temporal and spatial variation. It is a debilitating disease affecting the young adults with a propensity …
To monitor relative drug efficacy, serial monthly triple-dose (0.3 mmol/kg) Gadopentetate Dimeglumine (Magnevist, Befex, Montville, NJ) is being used for MRI's for more than eighteen consecutive occasions (every 4 weeks) in 75 patients. To our knowledge, no prior study has emplo…
Recent evidence suggests that autoimmunity against neuronal components may contribute not only to the neurological disfunction but also to the pathogenesis of Multiple sclerosis (MS). This include studies that have demonstrated axonal injury and loss in early MS and clinical ima…
Health-related quality of life (HRQL) is becoming a common outcome for many medical and rehabilitative studies. This is specifically true for multiple sclerosis (MS), one of the most common chronic neurological condition affecting young adults. As MS results in severe consequenc…
Multiple sclerosis (MS) is a chronic inflammatory disease that results in autoimmune demyelination of the human central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a widely-studied animal model of multiple sclerosis which reflects many of the histopa…
Vitamin D is an environmental factor known to protect against multiple sclerosis (MS). Furthermore, it has also been shown to influence activities of immunological genes such as the HLA-DRB1*1501, which have found to be associated with this autoimmune disease. Genes controlling …
Multiple sclerosis (MS) is the most common cause of acquired neurological disability in young adults. It is a multifocal disease defined histologically by multiple inflammatory lesions of demyelination, axonal injury, astrogliosis and varying degrees of remyelination. MS has two…
This dissertation is the first history of multiple sclerosis (MS) in the United States. This study subjected the archives of the National Institutes of Health, the Commonwealth Fund, the American Neurological Association, the New York Academy of Medicine, and the New York Hospit…
In the last two decades, advances in next-generation sequencing, genome-wide genotyping arrays, and methods to obtain DNA from ancient individuals have propelled the field of population genetics such that it is now an extraordinarily powerful tool for inferring human history. Th…
This dissertation investigates strategies for delineating the mechanisms and dynamics of disease progression that utilize innovative computational, statistical and mathematical strategies in conjunction with clinical and biomarker data. Structurally, this dissertation has two di…
Leukodystrophies (LDs) and genetically determined leukoencephalopathies (gLEs) are a heterogeneous group of rare genetic disorders of the cerebral white matter. LDs are primary disorders of the cerebral white matter (i.e. glial cells, myelin sheath), while gLEs include all leuko…
Purpose: People living with MS need to employ both problem and emotion-focused coping strategies to maintain optimal health. Specifically, with one’s Perceived Health Status as an indicator of optimal health, treatment adherence and religious coping are indicators of problem and…