The purpose of this study was to investigate morphological changes in the outflow pathway from Schlemm’s canal (SC) to the intrascleral vessels (ISVs) in POAG eyes through comparisons with age-matched, normal control eyes using light microscopy and morphometric analysis. We hypo…
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Introduction: Sleep apnea is an under recognized systemic condition with a variety of cardiovascular, ocular, and psychosocial complications. This records review was conducted to validate the clinical observation of an association between far peripheral retinal hemorrhages and s…
This dissertation is divided into three chapters, all originating from original fieldwork. Chapter One explores the impacts of blindness on blind subjects, their caretakers and their households in Amhara Region, Ethiopia, and demand for cataract surgery among those eligible for …
In clinical and preclinical studies it is common to observe correlated responses. Procedures for analysis of data from such studies include the use of generalized estimating equations, generalized mixed effects models and hierarchical modeling. George and Bowman (1995) propose a…
The retina is a complex stratified neural tissue required for all mammalian vision. During development, tightly controlled transcriptional regulation drives diversification from a homogenous population of retinal progenitor cells into seven major types and dozens of subtypes of …
Purpose: This study examined the effects of normobaric oxygen in patients diagnosed with either a Central Retinal Vein Occlusion (CRVO) or Branched Retinal Vein Occlusion (BRVO) who had previously undergone treatment via Anti-VEGF or PRP treatment. The investigation looked into …
During military operations in Iraq and Afghanistan, 16% of battlefield evacuations were attributable to ocular trauma. Potential for corneal opacification and vision loss is elevated if the corneal endothelium is damaged. The cornea is the outer-most clear part of the eye which …
Purpose: Diabetic macular edema (DME) is the most common cause of vision loss in patients with diabetic retinopathy. This study aims to approach diabetic macular edema and diabetic retinopathy as ischemic conditions and explores a potential treatment through hyperoxia. The study…
Laser in situ keratomileusis (LASIK) is a surgical technique used to correct refractive errors by reshaping the cornea. Although LASIK is superior to other visual correction techniques, recent clinical reports show that, in some cases, it leads to serious optical problems. There…
This thesis investigated the refractive, accommodative and colour vision status of young people with Down's syndrome (DS). Seven separate studies were conducted. Participants were recruited from the Cardiff Down's Syndrome Vision Research Unit. Abnormal refractive development wa…
Diabetic retinopathy is one of the leading causes of blindness in the United States. The early loss of visual acuity in diabetic retinopathy is often related to the development of edema within the macula. Macular edema develops when the ability of retinal pigment epithelium (RPE…
In the first study was conducted in a sample of patients from consulting Dr. Peset Ophthalmology University Hospital of Valencia. Using a prospective study the relationship between risk factors, clinical outcomes and levels of expression of mediators of inflammation and immune r…
The purpose of this study was to quantify the effects of phacoemulsification and posterior segment chamber lens placement on vitreous inflammatory and neovascular growth factors. More specifically, the effect of immediately preceding cataract surgery was compared to a history of…
The overall purpose of this dissertation was to investigate the influence of visual disruption on measures of postural stability, specifically in anterior cruciate ligament reconstruction (ACLR) individuals. Each of the two studies included in this dissertation evaluated postura…
Purpose: Von Hippel-Lindau (VHL) disease is a hereditary disorder that can lead to ophthalmic manifestations, including retinal capillary hemangioma (RCH). The diagnosis of RCH is often guided by wide-field fluorescein angiography. In some cases, optical coherence tomography ang…
Purpose: To identify inflammatory markers in glaucoma patients undergoing ophthalmic surgeries prospectively. Concurrently, assess the prevalence of autoimmune diseases in patients with primary open angle glaucoma (POAG) undergoing ophthalmic surgery retrospectively.
Purpose: Pediatric patients with closed-globe injury (CGI) and traumatic hyphema are at risk for elevated intraocular pressure (IOP), which can have devastating consequences. Presently, patients are seen on a frequent but arbitrary schedule to monitor IOP. We sought to develop a…
Glaucoma is the second leading cause of blindness and third leading cause of visual impairment worldwide; 180 million people suffer from a glaucomatous visual disability. Glaucoma is an ocular neurodegenerative disease with several risk factors. The major identified risk factors…