Introdução : A espiritualidade é o aspeto da humanidade que se refere à forma como os indivíduos procuram e expressam sentido e propósito e está frequentemente relacionada com o significante ou sagrado. A espiritualidade torna-se particularmente importante nos cuidados em fim de…
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Contraction in striated muscle is regulated by Ca+2 through the tropomyosin (Tm)-troponin (Tn) thin filament associated regulatory complex. The Tn complex is composed of three subunits: troponin C (TnC), troponin I (TnI), and troponin T (TnT). Troponin T has been proposed as a m…
The incidence of congestive heart failure (CHF) rises annually and, despite advances in medical treatments, the prognosis remains poor. Since CHF has no cure, the treatment is mostly supportive symptom management and prevention of exacerbation. Studies examining the impact of so…
Background: Cardiac resynchronisation therapy (CRT) is a pacemaker-based therapy for patients with heart failure and dyssynchrony manifest as prolonged QRS duration. Approximately 30% fail to respond either symptomatically or echocardiographically. The role of several echocardio…
Heart failure (HF) is one of the commonest complications of Diabetes Mellitus (DM) with the prevalence of DM reported at around 30% in many pivotal heart failure studies. However the pathophysiological mechanisms that contribute to HF development in diabetes are poorly understoo…
Heart disease remains the leading cause of death in the United States, but technology (e.g., pacemakers, defibrillators, and imaging systems) has dramatically lowered mortality associated with heart disease. In basic research science, integrative approaches with different tools …
Background. Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are essential to the treatment of heart failure with reduced ejection fraction (HFrEF). However, little data are available to determine whether their efficacy in reducing hospital…
Targeting of the narrow therapeutic index (NTI) drug warfarin is very challenging for patients and physicians alike. That's because subtherapeutic warfarin level can cause recurrence of the thromboembolic events while supratherapeutic level may significantly raise the bleeding r…
Splicing factors bind, in most cases, to a degenerate motif in the pre-mRNA of the target gene and either recruit or repel the spliceosome to/from nearby splice sites. Many splicing factors possess RNA-independent functions, such as protein-protein interactions in cellular compl…
Reducing patient length of stay (LOS) and readmission rates are constant goals of effective hospitals, and multidisciplinary rounds (MDR) are essential to meeting these metrics, especially with healthcare today requiring a team-based approach. This project sought to implement MD…
Sarcoidosis is a systemic inflammatory disease of unknown etiology in which granulomatous lesions form mostly in the lungs and the lymphatic system of patients. Although more than a century has passed since sarcoidosis was first described, our understanding of its etiology and c…
The value of inducibility remains a major source of interest both as a predictor for recurrent clinical atrial fibrillation (AF) post atrial flutter (AFL) ablation, and as a potential endpoint for AF ablation. Developing predictors of AF recurrence post atrial flutter ablation a…