Thesiss

A doença oncológica é considerada um problema de saúde pública a nível mundial devido á sua crescente morbilidade e mortalidade no século XXI. Esta doença apresenta, igualmente, um grande impacto social devido aos custos económicos ligados à prevenção, tratamento e reabilitação …

Prostate cancer (PCa) is the most commonly diagnosed cancer amongst Western males. PCa progression is strongly linked to steroid receptor signalling, however the modulation of steroid receptor expression in PCa is incompletely understood. Lipocalin 2 (LCN2) is a secreted protein…

Ubiquitination is an extremely important post-translational modification, regulating a wide variety of cellular processes including proteasomal degradation, subcellular targeting, endocytosis and DNA repair. The HECT class of E3 ligases catalyse the final step of ubiquitin conju…