Thesiss

Ubiquitination is an extremely important post-translational modification, regulating a wide variety of cellular processes including proteasomal degradation, subcellular targeting, endocytosis and DNA repair. The HECT class of E3 ligases catalyse the final step of ubiquitin conju…

Posttranslational modification of p53 plays important roles in regulating its stability and activity. In the first part of my PhD, my main goal was to study the target sites for Mdm2-mediated ubiquitination within the p53 protein molecule and to examine the regulation of p53 lev…