Thesiss

Oncolytic virotherapy is a promising field of cancer treatment in which replication-competent viruses, including adenoviruses (Ads), can infect and lyse tumor cells. Syrian hamsters, unlike mice, are semi-permissive to human adenovirus type 5 (Ad5) and provide a useful immunocom…

Serotonin (5-HT) has been implicated in regulating the circadian pacemaker activity of the mammalian suprachiasmatic nuclei (SCN). However, little is known concerning the nature of 5-HT release in the SCN. The present studies examined the regulation of SCN 5-HT release using in …

Oncolytic adenoviruses represent an innovative approach to cancer therapy. These vectors are typically evaluated in immunodeficient mice with human xenograft tumors. However, in addition to being immunodeficient, this model is limited because normal and cancerous mouse tissues a…

Stress affects virtually all organisms and can result in both physiological and behavioral changes. Conditioned defeat in Syrian hamsters is a model of stress-induced behavioral plasticity that occurs in a social context. In this model, hamsters are defeated by a larger, more ag…

Pronounced maternal hyperlipidemia during pregnancy is a high priority health concern as it produces offspring who are predisposed to dyslipidemia and cardiovascular disease risk. As the use of lipid-lowering drugs during pregnancy is contraindicated, lipid-lowering compounds su…