Serotonin (5-HT) has been implicated in regulating the circadian pacemaker activity of the mammalian suprachiasmatic nuclei (SCN). However, little is known concerning the nature of 5-HT release in the SCN. The present studies examined the regulation of SCN 5-HT release using in …
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In this thesis, we report on studies that investigated the roles of serotonin (5-hydroxytryptamine; 5-HT) and γ-aminobutyric acid (GABA) in the pathophysiology of mania and in the mechanism of action of the mood stabilizer, divalproex sodium (DVP) using neuroendocrine challenge …
Prolactin (PRL) is involved in a number of reproductively important functions, but the upstream mechanisms that regulate PRL are not well characterized. The hypotheses of this study were that light, serotonin, and stress increase plasma PRL; PRL receptor mRNA levels are correlat…
Physiological and behavioral rhythms are generated by the suprachiasmatic nucleus (SCN). The SCN can be roughly divided into two regions, the core and the shell. Within the core and the shell, various cellular markers and neuropeptides integrate afferent photic and non-photic si…
Pulmonary Arterial Hypertension (PAH) is a sever disorder characterized by high pulmonary artery pressure and pulmonary vascular resistance along with specific histological changes. Idiopathic PAH is a human disease of unknown origin that showed common characteristics to PHS/asc…