Thesiss

Oncolytic virotherapy is a promising field of cancer treatment in which replication-competent viruses, including adenoviruses (Ads), can infect and lyse tumor cells. Syrian hamsters, unlike mice, are semi-permissive to human adenovirus type 5 (Ad5) and provide a useful immunocom…

Two significant limitations of tissue specific replicative adenovirus (TSRAd) for cancer virotherapy are limited target specificity and efficacy. We have developed a TSRAd with a "Double Lock" mechanism to provide tighter transcriptional control. This was accomplished by placing…