A infeção por retrovírus contribui para o desenvolvimento de linfoma em gatos e, apesar de estar associada a uma menor sobrevida, os estudos mais recentes não apontam como um fator determinante na avaliação do prognóstico desses indivíduos. No entanto, estes estudos foram realiz…
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Follicular (FL) and Marginal zone (MZL) lymphomas are low grade B-cell non-Hodgkin lymphomas (LG-NHL) representing approximately 11% and 7% of all NHL, respectively. Systemic radio-immunotherapy (RIT) is a novel concept which entails a target-specific monoclonal antibody used to…
Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, compromising p53 activity. Therefore, lymphoma is a suitable model for studying therapeutic value of disrupting HDM2-p53 association by small-molecule inhibitors (SMIs). HDM2 SMIs have been developed a…
Previous studies of the pattern of lymphoma in multi-ethnic West Malaysian population have shown a high frequency of EBV association in childhood Hodgkin's lymphoma (HL) and adult NK/T-cell lymphomas, with a predilection of the former in Indians and the latter in Chinese. This t…
The unfolded protein response (UPR) is a complex signalling pathway activated in response to endoplasmic reticulum stress. In recent years, the UPR has been implicated in cancer and chemosensitivity, particularly in solid tumours. This thesis investigated the potential value of …