Neural stem cells (NSCs) have the capacity to proliferate and give rise to multiple major central nervous system cell types and represent a possible cell of origin in gliomagenesis. Deletion of the tumor suppressor gene Tp53 (p53) results in increased proliferation and self-rene…
"23" Result
Sort By:
Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, compromising p53 activity. Therefore, lymphoma is a suitable model for studying therapeutic value of disrupting HDM2-p53 association by small-molecule inhibitors (SMIs). HDM2 SMIs have been developed a…
The genomes of any two individuals will differ. This genomic difference can be attributed mainly to polymorphisms such as single nucleotide polymorphisms (SNPs) and point mutations. While certain SNPs have the potential to be used as predictors of disease states, point mutations…
Inhibiting inflammatory processes or eliminating inflammation represents a logical role in the suppression and treatment strategy of cancer. Several studies have shown that anti-inflammatory drugs (NSAIDs) have promise as anticancer agents while reducing metastases and mortality…
A key effect of human papillomavirus (HPV) infection is to disrupt the normal cell cycle in order to subvert the cellular DNA replication machinery. Morphologically, condylomata induced by high and low risk HPV types cannot be distinguished and many studies have shown that the p…
Energy production is a very important function for the cells to maintain homeostasis, survive and proliferate. Cellular energy can be produced either through oxidative phosphorylation (OXPHOS) in the presence of oxygen or glycolysis in its absence. Cancer cells, even in the pres…
In this work, the interaction between Mdm2 and Ribosomal Protein L26 was investigated, and its implications on Mdm2, L26 and p53 were examined. p53 plays a key role in protecting cells from tumor development. In response to various stress conditions, activated p53 arrests cell c…
Abstract not available.