Thesiss

Concomitant chemoradiation therapy based on platinum chemotherapeutic drugs (Pt-drugs) is a common treatment modality for several types of cancers and has dramatically improved patient survival. The radiosensitization capacity of Pt-drugs results essentially from their binding t…

There is a clear association between excessive exposure to estrogens and the development of cancer in several tissues including breast and endometrium. Premarin is the most widely dispensed prescription for estrogen replacement therapy in the U.S.A. in 1995. It contains 46% endo…

The disease course of mature B cell lymphoma such as plasma cell and lymphoplasmatic neoplasms are generally indolent, mimicking the low-grade (LG) non-hodgkin's lymphomas. Such LGL and indolent tumors include the chronic lymphocytic leukemia (CLL), Hairy-cell leukemia (HCL), Wa…

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives, has gained pace over the last couple of years, as they have enhanced aqueous solubility, without loss of biological activity, in contrast to parent bisnaphthalimide derivatives. Rec…

Energy production is a very important function for the cells to maintain homeostasis, survive and proliferate. Cellular energy can be produced either through oxidative phosphorylation (OXPHOS) in the presence of oxygen or glycolysis in its absence. Cancer cells, even in the pres…

DNA damage leads to the activation of the ATM and ATR kinases, which in turn cause either cell cycle arrest and DNA repair or apoptosis. In the first part of my thesis, we have demonstrated that the pro-apoptotic BID protein is phosphorylated by ATM in response to DNA damage, an…