Thesiss

CD47 is a 47-52 kDa membrane spanning glycoprotein, which has 5 known isoforms and is a member of the immunoglobulin superfamily (IgSF). It possesses a large extracellular N-terminal IgV like domain. CD47 acts as a 'do not eat me' signal and consequently as a marker of self. Mor…

Energy production is a very important function for the cells to maintain homeostasis, survive and proliferate. Cellular energy can be produced either through oxidative phosphorylation (OXPHOS) in the presence of oxygen or glycolysis in its absence. Cancer cells, even in the pres…

Oncolytic adenovirus (Ad) vectors are emerging as a promising form of cancer therapy agent. A major obstacle in the oncolytic Ad field is a proper animal model to study these vectors. Due to the species-specificity of Ads, such vectors are commonly evaluated in immunodeficient m…