Among women in Hong Kong, breast cancer is the second most commonly occurring cancer and the second leading cause of cancer mortality. Breast cancer is associated with two breast cancer susceptibility genes, BRCA1 and BRCA2. Mutations in the tumor suppressor gene, BRCA1, have be…
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It is vital for the survival of an organism that it can repair damage to its DNA. Exogenous and endogenous sources of damage are dealt with by a variety of repair pathways that have evolved to repair specific types of damage. Organisms in the archaeal domain, the third domain of…
The base excision repair protein, MBD4 (also known as MED1) is known to be transcriptionally coupled to a mismatch repair protein MLH1. To date the significance of this coupling has not been elucidated and the significance of MBD4 within the mismatch repair system and apoptotic …
The entire epidermis of patients with vitiligo exhibits accumulation of up to 10-3M concentrations of hydrogen peroxide (H₂O₂) (Schallreuter, Moore et al. 1999). Over the last decade our group and others have focused on the effect of H₂O₂-mediated oxidative stress on the functio…
It is increasingly recognised that individual risk of cancer may be related to genetically determined differences in the ability of cells to identify and repair DNA damage. Cell cycle based assays of chromosomal radiosensitivity provide the greatest power for discriminating diff…
DNA is constantly damaged by a variety of exogenous and endogenous sources. To maintain the integrity of the genome, different DNA repair mechanisms have evolved, which deal with different kinds of DNA damage. One of the DNA repair pathways, Nucleotide Excision Repair (NER), is …
Prostate cancer (PCa) is the fifth leading cause of cancer-related deaths amongst men worldwide. Androgen deprivation therapy (ADT) in combination with radiation therapy (XRT) is the standard of care for high-risk localized PCa. Unfortunately, most patients become resistant to A…